RUTHENIUM CATALYZED ALKYNE COUPLING REACTIONS

这项研究的长期目标是实现两个详细的 机理的理解和发展新的合成方法， 许多不同的炔偶合反应。过渡金属- 催化的炔偶联反应已广泛用于 合成各种各样的天然产物。 过渡金属 σ-乙炔化物配合物被认为是重要的中间体 这些反应中的一些反应。 本研究旨在研究 配位不饱和炔鎓的基本反应性 络合物对炔烃与烯烃的偶联反应的影响， 羰基化合物 本研究旨在探讨 这些炔的偶合反应。 具体计划提交给 探索不饱和炔鎓的催化活性 在这些反应中。 金属环戊二烯配合物已经被广泛地认为是关键的 在许多不同的炔低聚反应中的中间物种 反应. 新形成的茂环戊二烯配合物 催化乙炔和烯烃的线性偶联反应。 该提案描述了研究反应性的具体计划， 茂并环戊二烯络合物对 线性炔偶合反应。 本研究的具体目标 是研究的基本反应性和催化活性的 乙炔鎓和茂环戊二烯络合物 炔偶联反应，并建立详细的机制， 这些反应。

The long term objectives of this research are to achieve both detailed mechanistic understandings and to develop new synthetic methods for a number of different alkyne coupling reactions. Transition metal- catalyzed alkyne coupling reactions have been extensively utilized in the synthesis of a wide range of natural products. Transition metal sigma-acetylide complexes are considered to be important intermediate species in some of these reactions. This research proposes to study the fundamental reactivity of coordinatively unsaturated ruthenium-acetylide complexes toward the coupling reactions of alkynes with alkenes and carbonyl compounds. This research proposes to examine the mechanisms of these alkyne coupling reactions. Specific plans are presented to explore the catalytic activity of unsaturated ruthenium-acetylide species in these reactions. Metallacyclopentadiene complexes have been widely implicated as key intermediate species in a number of different alkyne oligomerization reactions. The newly formed ruthenacyclopentadiene complex was shown to catalyze the linear coupling reactions of acetylenes and olefins. The proposal describes specific plans to study the reactivity and catalytic activity of the ruthenacyclopentadiene complexes towards linear alkyne coupling reactions. The specific goals of this research are to study the fundamental reactivity and catalytic activity of the ruthenium-acetylide and ruthenacyclopentadiene complexes toward the alkyne coupling reactions, and to establish the detailed mechanisms of these reactions.