Catalytic Coupling Reactions via C-H and C-N Bond Activation

摘要 拟议研究的主要目标是设计和利用新型催化C-H键 药物复杂有机化合物合成的活化法 重要性。该项目的第一个目标是开发和利用催化C-H偶联 方法合成多个具有生物活性的靶分子，包括他莫昔芬， 塞利瓦酮和舒林酸。该项目的第二个目标是采用催化偶联方法。 通过C-N键裂解氨基酸衍生物来合成一些复杂的分子 具有医药重要性的药物，包括多奈哌齐和STX-1040。拟议的研究计划 旨在开发新的催化偶联方法来合成各种高价值的靶标 具有较强抗癌抗炎生物活性的分子 环境可持续的条件。该项目寻求一位博士后的资金支持。 一名助理和一名研究生执行拟议的项目。

ABSTRACT The major goal of the proposed research is to design and utilize novel catalytic C-H bond activation methods for the synthesis of complex organic compounds of phamaceutical importance. The first aim of the project is to develop and utilize the catalytic C-H coupling methods to synthesize a number of biologically active target molecules, including tamoxifen, celivarone and sulindac. The second aim of the project incorporates catalytic coupling method of amino acid derivatives via C-N bond cleavage to synthesize a number of complex molecules of pharmaceutical importance, including donepezil and STX-1040. The proposed research plan aims to develop novel catalytic coupling methods to synthesize a variety of high-value target molecules with potent anticancer and anti-inflammatory biological activities under environmentally sustainable conditions. The project seeks financial support of one postdoctoral associate and one graduate student to carry out the proposed project.