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Ruthenium Catalyzed Bond Activation Reactions

钌催化的键活化反应

基本信息

批准号：
7125799
负责人：
CHAE S YI
金额：
$ 22.05万
依托单位：
MARQUETTE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
起止时间：
1998-08-01 至 2010-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7125799
关键词：
alkenes amination catalyst chemical bond chemical synthesis heavy metals hydrocarbons method development ruthenium technology /technique development

项目摘要

DESCRIPTION (provided by applicant): The long term goal of this research is to study synthetic and mechanistic aspects of metal-catalyzed C-H and N-H bond activation reactions. Transition metal-catalyzed C-H and N-H bond activation reactions are powerful synthetic methods for forming a wide variety of natural products and pharmaceutical agents. For example, transition metal-catalyzed C-H bond activation reaction can directly introduce heteroatom functional groups to unreactive hydrocarbons under environmentally benign conditions. Transition metal-catalyzed hydroamination reaction is a highly effective method for forming amine compounds in an atom-economical fashion. Furthermore, asymmetric version of the hydroamination reaction has high potential for stereoselective formation of nitrogen compounds. The paramount challenge for these catalytic reactions is to design metal catalysts which are applicable to the synthesis of a variety of natural products and pharmaceutical agents. The major objective of the proposed research is to study the synthetic and mechanistic aspects of the ruthenium-catalyzed C-H bond activation of amines and hydroamination reactions. This research seeks to gain the reaction mechanisms for catalytic C-H bond activation of amines and hydroamination of alkenes by employing well-defined ruthenium complexes. The proposed research will provide new catalytic methods for the synthesis of anticancer drugs and anti-inflammatory agents.

描述（由申请人提供）：本研究的长期目标是研究金属催化的C-H和N-H键活化反应的合成和机理方面。过渡金属催化的C-H键和N-H键活化反应是合成多种天然产物和药物的有效方法。例如，过渡金属催化的C-H键活化反应可以在环境友好的条件下将杂原子官能团直接引入非反应性烃。过渡金属催化的氢胺化反应是一种原子经济的高效胺化合物合成方法。此外，氢化胺化反应的不对称形式具有立体选择性形成氮化合物的高潜力。这些催化反应的最大挑战是设计适用于合成各种天然产物和药剂的金属催化剂。本研究的主要目的是研究季铵盐催化的胺的C-H键活化和氢胺化反应的合成和机理。本研究旨在通过使用定义明确的钌配合物来获得催化胺的C-H键活化和烯烃氢胺化的反应机理。拟议的研究将为抗癌药物和抗炎剂的合成提供新的催化方法。