CATALYTIC C-C BOND FORMING REACTIONS

催化 C-C 键形成反应

• 批准号: 7355286
• 负责人: CHAE S YI
• 金额: $ 0.05万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-02-01 至 2007-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7355286
• 关键词: CATALYTIC; BOND; FORMING; REACTIONS

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Transition metal-catalyzed coupling reactions of alkenes and alkynes are effective methods of forming conjugated compounds that have wide range of applications in industrial processes and natural product syntheses. One of our group's current research goals is to study the fundamental aspects of catalytic carbon-carbon bond forming reactions of alkenes and alkynes. In particular, we employ well-defined ruthenium-acetylide and -alkylidene complexes as catalysts to study the detailed mechanisms for several new catalytic coupling reactions of alkenes and alkynes. We found that the in-situ formed ruthenium-acetylide complex 1 is an effective catalyst for the cross dimerization of alkynes. We also discovered that the metallacyclopentadiene 2 is a highly selective catalyst for the linear coupling reaction of acetylene and alkenes to yield heptatriene products. The newly synthesized cationic ruthenium-alkylidene complex 3 was found to be excellent catalyst for the hydrovinylation of alkynes. We are currently investigating the detailed reaction mechanisms, and are searching for the next generation of metal catalysts for coupling reactions of alkenes and alkynes.

该子项目是利用 NIH/NCRR 资助的中心拨款提供的资源的众多研究子项目之一。子项目和研究者 (PI) 可能已从另一个 NIH 来源获得主要资金，因此可以在其他 CRISP 条目中得到体现。列出的机构是中心的机构，不一定是研究者的机构。过渡金属催化的烯烃和炔烃的偶联反应是形成共轭化合物的有效方法，在工业过程和天然产物合成中具有广泛的应用。我们小组当前的研究目标之一是研究烯烃和炔烃催化碳-碳键形成反应的基本方面。特别是，我们采用明确的钌-乙炔和-亚烷基配合物作为催化剂来研究烯烃和炔烃的几种新催化偶联反应的详细机制。我们发现原位形成的钌-乙炔络合物1是炔烃交叉二聚的有效催化剂。我们还发现金属环戊二烯2是一种高选择性催化剂，用于乙炔和烯烃的线性偶联反应生成庚三烯产物。新合成的阳离子钌-亚烷基配合物3被发现是炔烃氢乙烯基化的优异催化剂。我们目前正在研究详细的反应机理，并正在寻找下一代用于烯烃和炔烃偶联反应的金属催化剂。