FASEB SUMMER CONFERENCE ON NEUROIMMUNOLOGY

此申请是对第五个联邦的支持请求 美国实验生物学学会夏季研究会议 关于神经免疫学的会议将于1998年7月在俄勒冈州威尔逊维尔举行。 来自不同学科的科学家越来越多地 对免疫系统和神经质之间的对话感兴趣 系统。过去，这一领域的主要努力来自于 免疫学家，他们试图解释免疫系统如何影响 神经系统在自身免疫等病理条件下的行为 神经系统疾病。人们对这种互惠关系知之甚少。 神经系统对免疫系统的影响更是知之甚少 关于双向交流。这一主题最近被 引起了神经生物学家和那些致力于 尤其是中枢神经系统创伤和退行性疾病。因此，它 现在已经很清楚：(A)一些曾经被认为是 只有免疫系统才能表达，神经系统也能表达； (B)免疫系统和神经系统之间存在串扰， 在完好的和受伤的中枢神经系统中；及。(C) 对话在某些方面对CNS来说是独一无二的，而在其他方面可能是 对所有组织来说都是通用的。 此外，该领域的快速发展使得有必要 重新评估中枢神经系统免疫相互作用的一些基本方面，包括 中枢神经系统的解剖、生理和功能方面的关系 免疫活性和相互作用。在过去，人们对免疫的兴趣 脑部疾病的参与仅限于自身免疫性疾病。 最近，有证据表明，几乎所有与神经有关的疾病 涉及免疫相关成分，作为其发病机制的一部分。 这改变了我们对治疗方法的看法，目前 用于治疗退行性疾病的医药行业 以及中枢神经系统创伤的治疗。应具备的基本方面 重新评估包括小胶质细胞在退行性变和 自身免疫性疾病，中枢神经系统免疫豁免，小胶质细胞分化， 它们接近中枢神经系统及其在创伤和退行性变中的作用 疾病。召集自己的神经免疫学家是很重要的 论坛，特别是因为这些进程涉及几个 纪律。

This application is a request for support for the fifth Federation of American Societies for Experimental Biology Summer Research Conference on Neuroimmunology to be held at Wilsonville, Oregon, in July 1998. Scientists from a variety of disciplines have become increasingly interested in the dialogue between the immune system and the nervous system. In the past, the major effort in this field came from immunologists, who attempted to explain how the immune system affects nervous system behavior under pathological conditions such as autoimmune diseases of the nervous system. Little is known about the reciprocal effect of the nervous system on the immune system and even less is known about the bi-directional communication. This subject has recently attracted the attention of neurobiologists in general, and those working on CNS trauma and degenerative diseases in particular. As a result, it has now become clear that: (a) some components once thought to be exclusive to the immune system are also expressed by the nervous system; (b) there is a cross-talk between the immune system and nervous system, both in the intact and the injured CNS; and (c) the nature of the dialogue is unique in certain aspects to CNS while other aspects might be common to all tissues. In addition, the rapid advances in the field make it necessary to reassess a number of basic aspects of CNS-immune interactions, including anatomical, physiological and functional aspects of the CNS in relation to immune activity and interaction. In the past, interest in immune involvement in brain diseases was restricted to autoimmune diseases. Recently it became evident that almost any nerve-related disease involves an immune-associated component as part of its pathogenesis. This alters our view of therapeutic approaches currently accepted in the pharmaceutical industry for treatment of degenerative diseases of the CNS as well as treatment of CNS trauma. The basic aspects which should be reassessed include the role of microglia in degenerative and autoimmune diseases, CNS immune privilege, microglia in differentiation, their accessibility to the CNS and their role in trauma and degenerative diseases. It is important to assemble neuroimmunologists in their own forum, particularly since these processes involve input from several disciplines.