SOLID-STATE INTRAOPERATIVE BETA CAMERA

这项提议的目标是开发一个术中测试版的原型 专门为成像Beta发射而设计的相机(IOBC) 放射性药物(如18F、124I、186Re和188Re) 转移到脑部或其他器官，如乳房、淋巴结、 甲状腺和其他疾病。该探头用于术中手术。 手术环境。病人被注射了一种寻找肿瘤的药物 手术前用放射性药物，手术过程中取出 肿瘤肿块被执行，然后使用IOBC对该部位进行成像 用于定位残留的亚临床肿瘤细胞的探针。拟议的系统 旨在显著提高肿瘤切除的成功率 通过允许更完全地去除亚临床肿瘤细胞来进行手术 而不会过度切除正常组织。术中贝塔试验 摄像机将使用一个小的、重量轻的可拆卸的头部，包括 对β高度敏感的256像素硅PIN阵列 颗粒，但对噪声伽马背景辐射不敏感。 在第一阶段可行性研究期间，我们将建造一个256像素的 阵列的原型，并根据以下方面来表征其性能 电子噪声、空间分辨率、灵敏度和一致性 对贝塔发射器的反应。此外，优化了扩增 电子设备将确保所需的高度 小型化和足够低的电子噪音。在第二阶段甲 完整的术中成像系统，包括微型探测器 探头、处理电子学、数据采集、图像处理和 将设计和开发显示硬件和软件。 建议的商业应用 需要商业化的术中成像摄像机来改进 肿瘤切除手术的成功。这可能会显著减少 手术时间缩短，手术成本相应降低。这 可以在相应减少的情况下显著减少手术时间 降低了手术费用，并导致更快的恢复和更低的恢复 成本。这项工作主要集中在一种新型的半导体β相机上。 系统具有可拆卸、紧凑和轻便的成像探头。 不同版本的探头可适用于乳房、淋巴 结节、甲状腺和其他器官。

The goal of this proposal is to develop a prototype intraoperative beta camera (IOBC) specifically designed for use in imaging beta emitting radiopharmaceuticals (such as 18F, 124I, 186Re, and 188Re) incorporated into tumors in the brain or other organs such as breast, lymph nodes, thyroid and others. The probe is intended for use in the intraoperative surgical environment. The patient is injected with a tumor seeking radiopharmaceutical before surgery, the surgical procedure to remove tumor mass is performed, and the site is then imaged using the IOBC probe to locate residual subclinical tumor cells. The proposed system is intended to significantly improve the success of tumor removal surgeries by allowing more complete removal of subclinical tumor cells without excessive removal of normal tissue. The intraoperative beta camera will use a small, and light-weight, detachable head comprising a 256-pixel silicon-PIN array which is highly sensitive to beta particles but insensitive to the noisy gamma background radiation. During the Phase I feasibility study we will construct a 256-pixel prototype of the array and characterize its performance in terms of electronic noise, spatial resolution, sensitivity, and uniformity of response to beta emitters. In addition, optimization of amplification electronics will be done to assure required high degree of miniaturization and sufficiently low electronic noise. In Phase II a complete intraoperative imaging system including miniaturized detector probe, processing electronics, data collection, image processing and display hardware and software will be designed and developed. PROPOSED COMMERCIAL APPLICATION There is a need for commercial intraoperative imaging cameras to improve the success of tumor removal surgeries. This could significantly reduce time in surgery with a commensurate decrease in cost of surgeries. This could significantly reduce time in surgery with a commensurate decrease in cost of surgery and leading to faster recovery and lower recovery cost. The proposed work is focused on a novel semiconductor beta camera system with detachable, compact, and lightweight imaging probe. Different versions of the probe could be adapted for breast, lymph nodes, thyroid, and other organs.