QUANTITATIVE PERFORMANCE ASSESSMENT OF THE AIDS DEMENTIA COMPLEX

这个新项目试图扩展神经心理学方面的工作。 在该计划的最初筹资阶段完成的评估。它的 目的是扩展目前量化绩效的方法 对ADC进行评估，重点放在可能证明 在针对潜在问题的多学科研究中具有价值 ADC的病理生理机制。从标准化程度很高的 程序中，本项目将建立一个连续的效用 性能任务(CPT)，使用持续的反应时间度量 注意ADC的特性。CPT作为一种敏感的、早期的 抗逆转录病毒治疗研究中治疗效果的衡量 针对潜在的神经病理生理机制的治疗 此外，我们亦会研究ADC。作为CPT措施的相关性，其 相应的事件相关电位(ERP)也将与 尊重ADC。CPT和与事件相关的潜在措施都将 在FDG/PET扫描期间与项目4合作进行研究。 这些研究的目的并不是要取代先前确立的 ADC的神经心理测评方法，但有待进一步发展 这一综合征的敏感损害指标可以起到 在研究治疗效果和潜力方面的重要作用 病理生理机制。在本计划的背景下，这些 研究将与区域大脑的研究相结合 代谢、定量核磁共振和脑电功率谱，并将发挥作用 DIRECT替代标记在相关研究中的重要作用 以及HIV-1感染对中枢神经系统的间接影响。

This new project seeks to extend the work on neuropsychological assessment accomplished in the Program's initial period of funding. Its objective is to extend the current method of quantitative performance evaluation of ADC, focussing on more sensitive measures that might prove valuable in multidisciplinary studies directed at the underlying pathophysiological mechanism of ADC. Starting with a well-standardized procedure, this project will establish the utility of a Continuous Performance Task (CPT), using a reaction time measure of sustained attention to characterize ADC. The utility of CPT as a sensitive, early measure of treatment effects in studies of anti-retroviral therapy and of therapies directed at potential neuropathophysiological mechanisms of ADC will also be studied. As a correlate of the CPT measure, its corresponding event related potential (ERP) will also be studied with respect to ADC. Both the CPT and event related potential measures will be studied during FDG/PET scanning in collaboration with Project 4. The objective of these studies is not to replace the previously established methods of the neuropsychological assessment of ADC, but to develop more sensitive measures of impairment in this syndrome that can play a significant role in studying treatment effects and potential pathophysiological mechanisms. In the context of this Program, these studies will be integrated with the studies of regional cerebral metabolism, quantitative MRI, and EEG power spectra, and will play an important role in correlative studies using surrogate markers of direct and indirect effects of HIV-1 infection of the CNS.