CORTICAL-SUBCORTICAL INTERACTION IN PD AND NORMAL SPEECH

拟议的研究将调查大脑皮质和皮质下区域之间的相互作用 正电子发射断层扫描测量局部脑血流量的语音产生 在帕金森病(PD)患者中，PD患者接受脑深部刺激(DBS) 丘脑底核(STN)和正常人。使用STN的DBS治疗PD提供了一种 可逆的改变皮质下区域活动的方法，包括纹状体、苍白球和 丘脑。虽然这种疗法在减少非语言运动症状方面很有效，但通常没有效果。 甚至对言语的负面影响，引发了人们对言语和非言语之间关系的质疑 帕金森病患者的言语运动控制，以及更普遍的关于皮质-皮质下相互作用的性质 演讲。我们先前观察到在尾状核rCBF和尾状核rCBF之间存在可靠的负相关 正常和共济失调患者额叶下部面积与语速的关系。拟议的研究将 通过映射进一步探索这种关系以及它被STN的PD和DBS改变的方式 在一系列受控言语产生任务中的大脑活动。并发测量和 随后对rCBF和语音产生的分析已经产生了对 影像数据的功能意义。拟议的研究应该会在以下方面取得重大进展 了解正常说话者和非说话者在说话过程中皮质-皮质下的相互作用 流畅性受到了PD和星展银行的影响。这个项目还将描述这种互动是如何 受任务需求的影响，以及PD、DBS和任务需求的交互方式。目标是更好地理解 正常和不流利言语中的皮层-亚皮层交互作用以及这种交互作用在特定言语中的作用 言语产生的方方面面。 清晰地说话的能力涉及到一个复杂的大脑系统，而这个系统并没有被完全理解。帕金森氏病 会干扰这种能力。这项研究将研究帕金森氏病和一种形式的 对说话过程中的大脑活动进行治疗，以更好地理解这一系统。这可能会导致新的治疗方法 治疗神经系统疾病中的语言障碍。

The proposed studies will investigate interactions between cortical and subcortical brain regions during speech production by measuring regional cerebral blood flow (rCBF) with positron emission tomography (PET) in Parkinson's disease (PD) subjects, PD subjects with deep brain stimulation (DBS) of the subthalamic nuclei (STN), and normal subjects. The use of DBS of the STN to treat PD provides a reversible means of modifying the activity of sub-cortical areas including the striatum, globus pallidus, and thalamus. While effective in reducing non-speech motor symptoms, this form of therapy often has no effect or even a negative effect on speech, raising questions about the relationship between speech and non- speech motor control in PD, and more generally, about the nature of cortical-subcortical interactions during speech. We have previously observed a reliable inverse relationship between rCBF in the caudate and inferior frontal area as a function of speech rate in normal and ataxic speakers. The proposed studies will further explore this relationship and the ways in which it is altered by PD and by DBS of the STN by mapping brain activity during a series of controlled speech production tasks. The concurrent measurement and subsequent analysis of rCBF and speech production has already produced significant insight into the functional significance of imaging data. The proposed studies should yield significant ^progress in understanding cortical-subcortical interactions during speech in normal speakers andin speakers whose fluency has been affected by PD and DBS. This project will also characterizehow such interactions are affected by task demands, and how PD, DBS, and task demands interact. The goal is to better understand cbrtical-subcprtical interactions in normal and dysfluent speech, and the role of-such interactions in specific aspects of speech production. The ability to speak clearly involves a complex brain system that is not fully understood. Parkinson's Disease interferes with this ability. This researchwill study the effects of Parkinson's Disease and one formof treatment on brain activity during speech to better understand this system. This may lead to new therapies for speech disorders in neurological diseases.