CORTICAL-SUBCORTICAL INTERACTION IN PD AND NORMAL SPEECH

PD 和正常言语中的皮质-皮质下相互作用

• 批准号: 7194257
• 负责人: JOHN J SIDTIS
• 金额: $ 36.47万
• 依托单位: NATHAN S. KLINE INSTITUTE FOR PSYCH RES
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7194257
• 关键词: Acoustics; Address; Affect; Area; Bilateral; Brain; Brain Mapping; Brain region; Cerebrovascular Circulation; Characteristics; Clinical; Complement; Complex; Corpus striatum structure; Data; Deep Brain Stimulation; Foundations; Functional Imaging; Gestures; Globus Pallidus; Goals; Image; Inferior; Inferior frontal gyrus; Language; Lead; Left; Lesion; Linguistics; Logic; Measurement; Measures; Modeling; Motor; Nature; Numbers; Parkinson Disease; Pattern; Performance; Play; Positron-Emission Tomography; Production; Range; Rate; Research; Research Personnel; Role; Sampling; Scanning; Series; Shapes; Speech; Speech Disorders; Structure; Structure of subthalamic nucleus; Symptoms; System; Testing; Thalamic Nuclei; Thalamic structure; Work; base; caudate nucleus; insight; motor control; nervous system disorder; predictive modeling; programs

DESCRIPTION (provided by applicant): The proposed studies will investigate interactions between cortical and subcortical brain regions during speech production by measuring regional cerebral blood flow (rCBF) with positron emission tomography (PET) in Parkinson's disease (PD) subjects, PD subjects with deep brain stimulation (DBS) of the subthalamic nuclei (STN), and normal subjects. The use of DBS of the STN to treat PD provides a reversible means of modifying the activity of sub-cortical areas including the striatum, globus pallidus, and thalamus. While effective in reducing non-speech motor symptoms, this form of therapy often has no effect or even a negative effect on speech, raising questions about the relationship between speech and non- speech motor control in PD, and more generally, about the nature of cortical-subcortical interactions during speech. We have previously observed a reliable inverse relationship between rCBF in the caudate and inferior frontal area as a function of speech rate in normal and ataxic speakers. The proposed studies will further explore this relationship and the ways in which it is altered by PD and by DBS of the STN by mapping brain activity during a series of controlled speech production tasks. The concurrent measurement and subsequent analysis of rCBF and speech production has already produced significant insight into the functional significance of imaging data. The proposed studies should yield significant progress in understanding cortical-subcortical interactions during speech in normal speakers and in speakers whose fluency has been affected by PD and DBS. This project will also characterize how such interactions are affected by task demands, and how PD, DBS, and task demands interact. The goal is to better understand cortical-subcortical interactions in normal and dysfluent speech, and the role of-such interactions in specific aspects of speech production. The ability to speak clearly involves a complex brain system that is not fully understood. Parkinson's disease interferes with this ability. This research will study the effects of Parkinson's disease and one form of treatment on brain activity during speech to better understand this system. This may lead to new therapies for speech disorders in neurological diseases.

描述（由申请人提供）：拟议的研究将通过使用正电子发射断层扫描（PET）测量帕金森病（PD）受试者，丘脑下核（STN）深部脑刺激（DBS）的PD受试者和正常受试者的区域脑血流量（rCBF）来研究大脑皮层和皮层下脑区域在言语产生过程中的相互作用。使用STN的DBS治疗PD提供了一种可逆的方法来改变皮层下区域的活动，包括纹状体、苍白球和丘脑。虽然这种形式的治疗在减少非言语运动症状方面有效，但通常对言语没有影响甚至是负面影响，这引起了人们对PD中言语和非言语运动控制之间关系的质疑，更普遍的是，关于言语过程中皮层-皮层下相互作用的本质。我们之前已经观察到，在正常和共济障碍者中，尾状和额下区域的rCBF与语速之间存在可靠的负相关关系。本研究将通过绘制一系列受控语音生成任务期间的大脑活动，进一步探索PD和STN DBS对这种关系的改变方式。rCBF和语音产生的同步测量和后续分析已经对成像数据的功能意义产生了重要的见解。在理解正常说话者和受PD和DBS影响的说话者在说话过程中的皮层-皮层下相互作用方面，拟议的研究将取得重大进展。该项目还将描述这些交互如何受到任务需求的影响，以及PD、DBS和任务需求如何交互。目的是更好地理解正常和不流利语言中皮层-皮层下的相互作用，以及这种相互作用在语言产生的特定方面的作用。清晰说话的能力涉及到一个复杂的大脑系统，我们还没有完全理解。帕金森氏症会干扰这种能力。这项研究将研究帕金森病和一种治疗方式对说话时大脑活动的影响，以更好地了解这一系统。这可能会导致神经系统疾病中语言障碍的新疗法。