CORTICAL-SUBCORTICAL INTERACTION IN PD AND NORMAL SPEECH

PD 和正常言语中的皮质-皮质下相互作用

• 批准号: 7094753
• 负责人: JOHN J SIDTIS
• 金额: $ 37.14万
• 依托单位: NATHAN S. KLINE INSTITUTE FOR PSYCH RES
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7094753
• 关键词: brain; clinical research; speech

DESCRIPTION (provided by applicant): The proposed studies will investigate interactions between cortical and subcortical brain regions during speech production by measuring regional cerebral blood flow (rCBF) with positron emission tomography (PET) in Parkinson's disease (PD) subjects, PD subjects with deep brain stimulation (DBS) of the subthalamic nuclei (STN), and normal subjects. The use of DBS of the STN to treat PD provides a reversible means of modifying the activity of sub-cortical areas including the striatum, globus pallidus, and thalamus. While effective in reducing non-speech motor symptoms, this form of therapy often has no effect or even a negative effect on speech, raising questions about the relationship between speech and non- speech motor control in PD, and more generally, about the nature of cortical-subcortical interactions during speech. We have previously observed a reliable inverse relationship between rCBF in the caudate and inferior frontal area as a function of speech rate in normal and ataxic speakers. The proposed studies will further explore this relationship and the ways in which it is altered by PD and by DBS of the STN by mapping brain activity during a series of controlled speech production tasks. The concurrent measurement and subsequent analysis of rCBF and speech production has already produced significant insight into the functional significance of imaging data. The proposed studies should yield significant progress in understanding cortical-subcortical interactions during speech in normal speakers and in speakers whose fluency has been affected by PD and DBS. This project will also characterize how such interactions are affected by task demands, and how PD, DBS, and task demands interact. The goal is to better understand cortical-subcortical interactions in normal and dysfluent speech, and the role of-such interactions in specific aspects of speech production. The ability to speak clearly involves a complex brain system that is not fully understood. Parkinson's disease interferes with this ability. This research will study the effects of Parkinson's disease and one form of treatment on brain activity during speech to better understand this system. This may lead to new therapies for speech disorders in neurological diseases.

描述（由申请方提供）：拟定研究将通过使用正电子发射断层扫描（PET）测量帕金森病（PD）受试者、接受丘脑底核（DBS）深部脑刺激（DBS）的PD受试者和正常受试者的局部脑血流量（rCBF），研究言语产生期间皮质和皮质下脑区域之间的相互作用。使用DBS治疗帕金森病提供了一种可逆的方法，可以改变包括纹状体、苍白球和丘脑在内的皮质下区域的活动。虽然有效地减少非言语运动症状，但这种形式的治疗通常对言语没有影响，甚至是负面影响，这引起了关于PD中言语和非言语运动控制之间关系的问题，更一般地说，关于言语期间皮质-皮质下相互作用的性质。我们以前已经观察到一个可靠的反向关系rCBF在尾状核和额下区作为一个功能的语音速率在正常和共济失调的扬声器。拟议的研究将进一步探讨这种关系，以及PD和DBS在一系列受控语音产生任务中通过映射大脑活动来改变这种关系的方式。同时测量和随后的分析rCBF和语音产生已经产生了显着的洞察成像数据的功能意义。拟议中的研究应产生显着的进展，在理解皮层皮层下的相互作用，在讲话过程中，在正常的扬声器和扬声器的流畅性已受到PD和DBS。该项目还将描述这种交互如何受到任务需求的影响，以及PD，DBS和任务需求如何相互作用。我们的目标是更好地了解正常和不流利的语音皮层下的相互作用，以及在语音产生的特定方面的作用，这种相互作用。清楚地说话的能力涉及一个复杂的大脑系统，但尚未完全了解。帕金森氏症会干扰这种能力。这项研究将研究帕金森病和一种治疗方式对说话时大脑活动的影响，以更好地了解这个系统。这可能会导致新的治疗语言障碍的神经系统疾病。