CORTICAL-SUBCORTICAL INTERACTION IN PD AND NORMAL SPEECH

拟议中的研究将调查大脑皮层和皮层下区域之间的互动， 用正电子发射断层扫描测量局部脑血流量（rCBF）研究言语产生 (PET)在帕金森病（PD）受试者中，接受脑深部电刺激（DBS）的PD受试者 丘脑底核（subthalamic nucleus，简称STN）和正常受试者。使用DBS治疗帕金森病提供了一个 可逆的方法来改变皮质下区域的活性，包括纹状体，苍白球， 丘脑虽然有效地减少非言语运动症状，这种形式的治疗往往没有效果 甚至是对言语的负面影响，提出了关于言语和非言语之间关系的问题， PD中的言语运动控制，以及更普遍地，关于在PD过程中皮质-皮质下相互作用的性质， 演讲我们以前已经观察到尾状核的rCBF与 正常和共济失调说话者的下额叶面积与语速的关系拟议的研究将 进一步探讨这种关系，以及PD和DBS对脑电地形图的影响 大脑活动在一系列受控的语音生产任务。同时测量和 随后对rCBF和言语产生的分析已经对 成像数据的功能意义。拟议的研究应在以下方面取得重大进展： 理解正常说话者和 流畅性受到PD和DBS的影响。这个项目也将描述这种相互作用是如何 受任务需求的影响，以及PD，DBS和任务需求如何相互作用。我们的目标是更好地理解 正常和不流利言语中的cbrtical-subcprtical相互作用，以及这种相互作用在特定语言中的作用。 言语生产的各个方面。 清楚地说话的能力涉及到一个复杂的大脑系统，但尚未完全了解。帕金森病 干扰这种能力。这项研究将研究帕金森病和一种形式的 治疗在说话时的大脑活动，以更好地了解这个系统。这可能会导致新的疗法 治疗神经疾病中的言语障碍

The proposed studies will investigate interactions between cortical and subcortical brain regions during speech production by measuring regional cerebral blood flow (rCBF) with positron emission tomography (PET) in Parkinson's disease (PD) subjects, PD subjects with deep brain stimulation (DBS) of the subthalamic nuclei (STN), and normal subjects. The use of DBS of the STN to treat PD provides a reversible means of modifying the activity of sub-cortical areas including the striatum, globus pallidus, and thalamus. While effective in reducing non-speech motor symptoms, this form of therapy often has no effect or even a negative effect on speech, raising questions about the relationship between speech and non- speech motor control in PD, and more generally, about the nature of cortical-subcortical interactions during speech. We have previously observed a reliable inverse relationship between rCBF in the caudate and inferior frontal area as a function of speech rate in normal and ataxic speakers. The proposed studies will further explore this relationship and the ways in which it is altered by PD and by DBS of the STN by mapping brain activity during a series of controlled speech production tasks. The concurrent measurement and subsequent analysis of rCBF and speech production has already produced significant insight into the functional significance of imaging data. The proposed studies should yield significant ^progress in understanding cortical-subcortical interactions during speech in normal speakers andin speakers whose fluency has been affected by PD and DBS. This project will also characterizehow such interactions are affected by task demands, and how PD, DBS, and task demands interact. The goal is to better understand cbrtical-subcprtical interactions in normal and dysfluent speech, and the role of-such interactions in specific aspects of speech production. The ability to speak clearly involves a complex brain system that is not fully understood. Parkinson's Disease interferes with this ability. This researchwill study the effects of Parkinson's Disease and one formof treatment on brain activity during speech to better understand this system. This may lead to new therapies for speech disorders in neurological diseases.