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BEHAVIORAL CONTROL OF BREATHING

呼吸的行为控制

基本信息

批准号：
2883211
负责人：
JOHN M OREM
金额：
$ 13.84万
依托单位：
TEXAS TECH UNIVERSITY HEALTH SCIS CENTER
依托单位国家：
美国
项目类别：
财政年份：
1986
资助国家：
美国
起止时间：
1986-07-01 至 2001-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/2883211
关键词：
afferent nerve apnea behavioral /social science research tag behavioral medicine brain stem cats medulla oblongata neurons pons pulmonary respiration respiratory airway pressure respiratory function respiratory muscles respiratory reflex sleep swallowing wakefulness

项目摘要

Behavioral control of the respiratory system involves voluntary acts such as breathholding and reflexive acts such as sneezing, coughing, and swallowing. All of these acts are stat e-dependent and generally occur only in wakefulness. Many are important for defense of the airways. For example, in addition to its role in alimentation, swallowing is the final act in clearance of mucous from the airways. Impaired swallowing, coughing and sneezing lead to aspiration and/or irritation of the airways, which are incompatible with life. Behavioral control of the respiratory system is poorly understood. Our studies of normal animals trained to perform a behavioral respiratory response show that control in this case occurs within the automatic system of the brainstem. When inspiration is stopped behaviorally, inspiratory neurons in the brainstem are inactivated. This inactivation is not caused by cells that inhibit inspiratory neurons during normal breathing. It may be caused instead by cells that receive both respiratory and nonrespiratory inputs (low n2 cells). These cells may act as an interface that mediates behavioral and reflexive control of the respiratory system. The studies of this proposal will test this theory. We will determine if low n2 cells that are activated during behavioral inhibition of inspiration are activated also by stimuli that cause reflexive apneas and the defensive respiratory responses of sneezing, coughing, and swallowing. To this end, brainstem respiratory neuronal activity and respiratory muscle activity will be recorded during defensive respiratory responses elicited by nasal, pharyngeal, and tracheobronchial stimulation in wakefulness and NREM and REM sleep in intact adult cats. These studies will address the neural mechanisms of apnea, the coordination of the respiratory system during sneezing, coughing and swallowing, and the effect of sleep on defensive respiratory responses.

呼吸系统的行为控制涉及自愿行为，例如屏气和反射性行为，如打喷嚏、咳嗽等吞咽。所有这些行为都依赖于状态并且通常会发生只有在清醒的时候。许多对于保护呼吸道很重要。为了例如，除了其营养作用外，吞咽是最后的作用清除呼吸道粘液。吞咽困难、咳嗽打喷嚏会导致误吸和/或刺激呼吸道，这是与生活不相容。人们对呼吸系统的行为控制知之甚少。我们的对接受行为呼吸训练的正常动物进行的研究响应表明这种情况下的控制发生在自动系统内脑干的。当吸气在行为上停止时，吸气脑干中的神经元失活。这种失活不是由由在正常呼吸期间抑制吸气神经元的细胞产生。它可能相反，是由接受呼吸和呼吸的细胞引起的非呼吸输入（n2 细胞低）。这些细胞可以充当接口介导呼吸系统的行为和反射控制。该提案的研究将检验这一理论。我们将确定是否低 n2 细胞在吸气行为抑制期间被激活也会被导致反射性呼吸暂停和防御性呼吸暂停的刺激激活打喷嚏、咳嗽和吞咽等呼吸道反应。为此，脑干呼吸神经元活动和呼吸肌活动将在鼻引起的防御性呼吸反应期间被记录，清醒状态和 NREM 状态下的咽部和气管支气管刺激完整成年猫的快速眼动睡眠。这些研究将解决神经呼吸暂停的机制，呼吸系统的协调打喷嚏、咳嗽和吞咽，以及睡眠对防御的影响呼吸反应。

项目成果

期刊论文数量（27）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Hypocapnia decreases the amount of rapid eye movement sleep in cats.

低碳酸血症会减少猫的快速动眼睡眠时间。

DOI：
10.1093/sleep/26.8.961
发表时间：
2003
期刊：
Sleep
影响因子：
5.6
作者：
Lovering,AndrewT;Fraigne,JimmyJ;Dunin-Barkowski,WitaliL;Vidruk,EdwardH;Orem,JohnM
通讯作者：
Orem,JohnM

Activity of medullary respiratory neurons during ventilator-induced apnea in sleep and wakefulness.

睡眠和清醒时呼吸机引起的呼吸暂停期间髓质呼吸神经元的活动。