BEHAVIORAL CONTROL OF BREATHING

呼吸的行为控制

• 批准号: 3336428
• 负责人: JOHN M OREM
• 金额: $ 10.18万
• 依托单位: TEXAS TECH UNIVERSITY HEALTH SCIS CENTER
• 依托单位国家: 美国
• 财政年份: 1986
• 资助国家: 美国
• 起止时间: 1986-07-01 至 1994-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3336428
• 关键词: REM sleep; afferent nerve; behavioral medicine; brain mapping; brain stem; cats; computer data analysis; electroencephalography; electromyography; experimental brain lesion; histochemistry /cytochemistry; medulla oblongata; microelectrodes; motor neurons; neural information processing; neuroanatomy; pons; psychobiology; pulmonary respiration; respiration regulatory center; respiratory airflow disorder; respiratory airway pressure; respiratory center dysfunction; respiratory muscles; single cell analysis; sleep; stimulus /response; wakefulness

The patterns of breathing change across states--presumably because of changing inputs to brainstem respiratory neurons. These inputs include those for behavioral control in wakefulness-and possibly in rapid eye movement sleep--, and they may increase or decrease respiration. Little is known of the interaction of these afferents with brainstem respiratory neurons. Proposed herein are tests of a hypothesis about the integration of state-related afferents within the respiratory system. This hypothesis proposes that state-related afferents engage a class of respiratory cell that acts as an interface between afferents having nonrespiratory forms and the respiratory cells of the oscillator. These cells of the interface, it is proposed, have respiratory activity that is weakened and distorted by nonrespiratory inputs that change in different states. In contract, other respiratory cells, putatively those of the oscillator, have strong and consistent respiratory activity, are unresponsive to nonrespiratory inputs and less affected by changed in state. The mode of interaction of the cells of the interface with the cells of the oscillator is unknown. It is assumed, however, that a subset of the former is activated to inhibit the latter when breathing is stopped behaviorally. To test these ideas, the activity of respiratory neurons will be recorded in the medullary and pontine respiratory groups during sleep and wakefulness, during behavioral control of breathing, and in response to sensory stimuli. These studies of intact, unanesthetized animals are significant for understanding behavioral control of breathing, breathing in sleep, integration of nonrespiratory afferents within the respiratory system, and the nature of the respiratory oscillator.

呼吸模式在不同状态下会发生变化——大概是因为 改变脑干呼吸神经元的输入。 这些输入包括 用于清醒时以及可能快速眼动时的行为控制 运动睡眠——它们可能会增加或减少呼吸。 小的 已知这些传入神经与脑干呼吸的相互作用 神经元。 本文提出了关于集成的假设的检验 呼吸系统内与状态相关的传入。 这 假设提出，与状态相关的传入涉及一类 呼吸细胞充当传入神经之间的界面 非呼吸形式和振荡器的呼吸细胞。 这些 据建议，界面细胞具有呼吸活动，即 因不同程度变化的非呼吸输入而减弱和扭曲 州。 合同中，其他呼吸细胞，大概是那些 振荡器，具有强烈且一致的呼吸活动，是 对非呼吸输入反应迟钝，受环境变化影响较小 状态。 界面细胞与界面的相互作用模式 振荡器的单元未知。 然而，假设 当呼吸停止时，前者的子集被激活以抑制后者。 行为上停止了。 为了检验这些想法，呼吸活动 神经元将被记录在延髓和脑桥呼吸组中 在睡眠和清醒期间，在呼吸的行为控制期间，以及 对感官刺激作出反应。 这些研究是对完整的、未麻醉的 动物对于理解行为控制具有重要意义 呼吸、睡眠中的呼吸、非呼吸传入的整合 在呼吸系统内，以及呼吸的性质 振荡器。