FUNCTIONAL NEUROANATOMY OF FEAR CONDITIONING

这个项目的长期目标是提高我们对 人脑中的神经系统如何抑制厌恶情绪 通过评估大脑代谢活动来像恐惧和焦虑这样的状态 健康志愿者的功能磁共振成像研究 (功能磁共振成像)。具体地说，这个项目将集中在收购和 动态评估巴甫洛夫恐惧条件反射的表现 学习过程中区域激活的变化以及当 恐惧反应被表达出来。这些目标将通过两个方面来实现 实验。在第一个实验中，志愿者将接受初步培训 (收购)害怕中性刺激。然后他们的记忆中 将对以前的培训(绩效)进行评估。功能和 在采集和采集过程中将获得解剖图像 表演阶段。在第二个实验中，志愿者将被 经过差异化训练以害怕一种刺激(Cspus)，而不是害怕 第二刺激(CS-)。在这个实验中，受试者将充当他们的 自己控制，探测器试验将用来进行比较 不带UCS演示文稿。这些实验将回答问题 关于哪些神经结构参与学习和表达 将描述激活的时间模式 在这些结构中，将提供对如何参与的洞察 随着学习的发生和恐惧的表达，各种结构发生变化， 并将其与学习动物模型系统进行比较。将数据发送到 将极大地促进我们对 人类恐惧和焦虑的神经解剖机制，并可能 直接有助于改进评估和治疗 情感障碍。

The long term goal of this project is to improve our understanding of how neural systems in the human brain subserve aversive emotional states like fear and anxiety by assessing the brain metabolic activity of healthy volunteers with Functional Magnetic Resonance Imaging (fMRI). Specifically, this project will focus on the acquisition and performance of Pavlovian fear conditioning by assessing dynamic changes in regional activation during the learning process and when a fear response is expressed. These goals will be achieved with two experiments. In the first experiment, volunteers will be initially trained (acquisition) to fear a neutral stimulus. Then their memory for the previous training (performance) will be assessed. Functional and anatomical images will be obtained during both acquisition and performance phase. In the second experiment, volunteers will be differentially trained to fear one stimulus (Csplus) and not to fear a second stimulus (CS-). In this experiment, subjects will serve as their own control, and Probe trials will be used to make comparisons without UCS presentation. These experiments will answer questions about which neural structures are involved in learning and expression of conditional fear, will describe the temporal pattern of activation within these structures, will provide insights into how the involvement of various structures change as learning occurs and fear is expressed, and will comparisons with learning animal model systems. The data to be collected will substantially advance our understanding of neuroanatomical mechanisms of human fear and anxiety, and may directly contribute to improvements in the assessment and treatment of affective disorders.