FAST ELECTRICAL OSCILLATIONS IN SOMATOSENSORY CORTEX

也许是最古老、最广为人知、最不为人所知的 人类大脑的电现象是疾病和健康 它特有的大振幅电振荡最近， 在理解这种关系方面有了重大进展， 脑震荡和脑功能之间的联系皮层电 高频伽马波段（约40 Hz）的振荡似乎 在信息处理的时间同步中发挥作用 在感觉皮层。然而，它们的功能意义和机制， 神经发生仍然是一个充满猜测和争议的问题。 在本实验系列中，这两个问题都将通过以下方式解决： 执行所述二维分布的高分辨率映射 诱发的和自发的伽马振荡 使用64通道电极阵列在大鼠中的触须/桶皮质，以及 通过将这些时空图与同步记录进行比较 在躯体感觉丘脑的特异性和非特异性核团中进行。 先前在听觉系统中获得的结果，涉及丘脑 皮质伽马振荡的调制，将首先外推 到躯体感觉系统，建立结构和功能 类比，应该强烈支持或反驳的假设， 不同的丘脑系统参与生成或 皮层伽马振荡的调制。第二，可能 丘脑-皮层神经回路的同步化 在伽马振荡期间将被研究。 丘脑皮质触须 在个体皮质柱水平上的相互作用。 空间 鼻毛/桶中伽马振荡的时间特性 场，和可能的丘脑皮层同步，将在 未麻醉和不受约束的大鼠发出主动触觉的气味， 辨别任务 这些实验将为理解 啮齿动物γ振荡的神经发生及其相互关系 基础解剖和突触神经支配，弥合了一个主要的差距， 我们对单细胞特性和 更大的多突触神经系统的特性。 这些实验 也将提供一个起点，传导类似更有限 这是我们研究计划的长期目标。

Perhaps the oldest, most widely recognized, and least understood electrical phenomena of the human brain is sickness and in health are its characteristic large amplitude electrical oscillations. Recently, there has been a major advance towards understanding the relationship between brain oscillations and brain function. Electrocortical oscillations in the high frequency gamma band (approx.40 Hz) appear to play a role in the temporal synchronization of information processing in sensory cortex. Yet, their functional significance and mechanism of neurogenesis is still a matter of much speculation and controversy. In this experimental series, both of these issues will be addressed by performing high resolution mapping of the two dimensional distribution of evoked and spontaneous gamma oscillation on the surface of vibrissa/barrel cortex in the rat using 64 channel electrode arrays, and by comparing these spatiotemporal maps to concurrent recordings performed in specific and nonspecific nuclei of somatosensory thalamus. Results previously obtained in the auditory system, concerning thalamic modulation of cortical gamma oscillations, will first be extrapolated to the somatosensory system, to establish structural and functional analogies that should strongly support or refute hypothesis about the participation of distinct thalamic systems in the generation or modulation of cortical gamma oscillations. Second, possible synchronization within reciprocally connected thalamocortical circuits during gamma oscillation will be studied. The vibrissa thalamocortical interactions at the level of individual cortical columns. The spatial and temporal properties of gamma oscillation in the vibrissa/barrel field, and possible thalamocortical synchronization, will be studied in the unanesthetized and unrestrained rat perfuming an active tactile discrimination task. These experiments would provide a basis for understanding the neurogenesis of gamma oscillations in the rodent, and their relationship to underlying anatomy and synaptic innervation, bridging a major gap in our understanding between single cell properties and the response properties of larger multi-synaptic neural systems. These experiments will also provide a starting point for conduction similar more limited studies in humans, the long range goal of our research program.