NEURAL AND ENDOCRINE BASIS OS SELF-STIMULATION OF OVARIAN DEVELOPMENT/DOVES

先前的研究已经表明，电解性损伤在 雌激素敏感的丘间核(ICO)破坏 雌性筑巢和雄性求偶诱导卵巢发育 在鸽子圈里。在这个提案中，我们分析了潜在的神经 电路和神经内分泌机制及其方法 电解性损伤、选择性化学损伤、电生理损伤 录音和免疫组织化学。三个相互关联的研究 建议：(1)研究ICO神经元的作用；(2)研究ICO神经元的作用 端脑中枢，如雌激素牛带核 向ICO发送投影的敏感区域，以及(3)角色 向视前-下丘脑前部的ICO投射， 促性腺激素释放激素集中的区域 神经元，关于巢鸣叫显示(发声)的产生 和姿势成分)和卵巢对不同COO的反应。 这些研究的长期目标是描绘出神经和 行为调节的内分泌机制 卵巢活动。这些研究路线最终可能有助于 了解和控制常见的临床现象，如 通过以下方式提高妇女怀孕的机会 领养一个。

It has been shown in previous studies that electrolytic lesions in the estrogen-sensitive nucleus intercollicularis (ICo) disrupt female nest-coos and male courtship induced ovarian development in the ring dove. In this proposal we analyze the underlying neural circuitry and neuroendocrine mechanisms with the methods for electrolytic lesion, selective chemical lesion, electrophysiological recordings and immunohistochemistry. Three interrelated studies are proposed: (1) Study of the role of the ICo neurons, (2) Role of telencephalic centers, such as nucleus taenia, an estrogen sensitive region which sends projections to the ICo, and (3) Role of the ICo projections to pre-optic-anterior hypothalamic region, an area concentrated with gonadotrophin releasing hormone neurons, with respect to the production of nest-coo display (vocal and posture component) and ovarian response to different coos. The long-term goal of these studies is to delineate the neural and endocrine mechanisms underlying the behaviorally mediated ovarian activity. These lines of studies may eventually help to understand and control of well-known clinical phenomenon such as the promotion of a woman's chance to conceive a child by adopting one.