NEUROBIOLOGICAL STUDY OF VOCALIZATION

该项目的长期目标是确定生物 论发声的“非交际性”功能及其意义 描述潜在的生理机制。 尽管发声传统上被认为是一种 通信，最近来自我的实验室的证据有力地表明 交流也是一种整体的生理能力。 鸟鸣，特别是在雀形目动物中，长期以来一直是一项受欢迎的研究 系统。歌唱发展中的学习问题与适应 声学通信的意义是具有 已经解决了。最主要的问题是，男性 歌声可能会影响雌性的内分泌反应，最终产生卵子-- 铺设，还没有人研究过。然而，这个问题一直是 深入研究非鸣禽系统。研究中的最新发现 雌性环鸽(Streptopelia Risoria)的生殖系统已被揭示 发声的一个有趣的方面，但几乎没有收到什么 请注意。我们发现鸟类的发声改变了它的内分泌 州政府。是什么神经通路调节了这种内分泌反应？我们能不能 用形态学来证明这一基本发现？有什么不同吗 求爱与其他性爱的内分泌结果所涉及的回路 发声，比如闹铃？在此应用程序中，我将确定 并描述了中介神经通路的化学特征 发声转化为内分泌反应。换句话说，我们 意在证明黄体生成素释放增加 荷尔蒙(LHRH)的释放可以追溯到发声神经元的活动 控制与雌性筑巢行为相关的核团。 拟议的研究将增加关于声学输入如何、 尤其是那些由个体自己的发声影响产生的声音 内分泌状态，从而影响个体的健康。

The long term objective of this project is to determine the biological significance of the "non-communicative" function of vocalization and characterize the underlying physiological mechanisms. Although vocalization has traditionally been viewed as a mean of communication, recent evidence from my laboratory strongly indicates that communication also function in an integral physiological capacity. Birdsong, especially in passerine species, has long been a favored research system. The issue of learning in development of song and adaptive significance of acoustic communication are among the problems which have been addressed. The primary question of the mechanism by which the male song may influence the female's endocrine response, culminating in egg- laying, has not been studied. However, this issue has been subject of intensive study of non-songbird system. Recent findings in the study of the female ringdove (Streptopelia risoria) reproductive system has revealed an interesting dimension of vocalization which has received little attention. We have found that a bird's vocalization alters its endocrine state. What neural pathways mediate this endocrine response? Can we demonstrate this basic finding in morphological terms? Are there different circuities involved in endocrine consequence of courtship vs other vocalization such as alarm calls? In this application, I will determine and characterize the chemical features of the neural pathways which mediate the conversion of vocalization into endocrine response. In other words, we intend to demonstrate that an increased luteinizing hormone-releasing hormone (LHRH) release can be traced to neuronal activity in the vocal control nuclei associated with the performance of female nest calls. The proposed studies will add useful information about how acoustic inputs, especially those generated from the individual's own vocalization affect endocrine state and hence the well-being of the individual.