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ORAL RANGE AND TOXICITY OF 2,3-DITHIOL-3-THIONE

ORAL RANGE AND TOXICITY OF 2,3-DITHIOL-3-THIONE
2,3-二硫醇-3-硫酮的口服范围和毒性
批准号：
2879216
负责人：
BARRY S LEVINE
金额：
$42.38万
依托单位：
UNIVERSITY OF ILLINOIS AT CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
未结题
起止时间：
1998-09-30 至
来源：
https://reporter.nih.gov/project-details/2879216
关键词：
antineoplastics behavior test blood tests clinical chemistry cytochrome P450 dithiol dogs dosage drug administration rate /duration drug adverse effect drug screening /evaluation eating hematology histopathology laboratory rat oral administration thiones urinalysis water drinking behavior

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中文摘要
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英文摘要
A 14-day, oral rangefinding study will be conducted in rats to identify the dose limiting toxicities of 1,2-dithiol-3-thione. Endpoints will include behavioral assessment, food & water consumption, and clinical and anatomical pathology. Twenty-eight day, repeat-dose, oral studies will then be conducted in rats and dogs. Endpoints will include food and water consumption, body weight, clinical observation, cardiac and ophthalmic assessment, clinical chemistry and hematology, plasma test agent levels, urinalysis, and anatomic and histologic pathology. Biochemical evaluation of cytochrome P450 isoenzyme and phase 2 enzyme modulation will be conducted. Dose associated toxicities will be identified.
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FOURTEEN DAY ORAL RANGEFINDING STUDIES AND TWENTY-EIGHT
TOXICOLOGICAL EVALUATIONS OF POTENTIAL MEDICATIONS TO
FOURTEEN DAY ORAL RANGEFINDING STUDY IN RATS AND DOGS AN
TOXICOLOGICAL EVALUATIONS OF POTENTIAL MEDICATIONS TO
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