ORAL RANGE AND TOXICITY OF 2,3-DITHIOL-3-THIONE

2,3-二硫醇-3-硫酮的口服范围和毒性

• 批准号: 2879216
• 负责人: BARRY S LEVINE
• 金额: $ 42.38万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-30 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2879216
• 关键词: antineoplastics; behavior test; blood tests; clinical chemistry; cytochrome P450; dithiol; dogs; dosage; drug administration rate /duration; drug adverse effect; drug screening /evaluation; eating; hematology; histopathology; laboratory rat; oral administration; thiones; urinalysis; water drinking behavior

A 14-day, oral rangefinding study will be conducted in rats to identify the dose limiting toxicities of 1,2-dithiol-3-thione. Endpoints will include behavioral assessment, food & water consumption, and clinical and anatomical pathology. Twenty-eight day, repeat-dose, oral studies will then be conducted in rats and dogs. Endpoints will include food and water consumption, body weight, clinical observation, cardiac and ophthalmic assessment, clinical chemistry and hematology, plasma test agent levels, urinalysis, and anatomic and histologic pathology. Biochemical evaluation of cytochrome P450 isoenzyme and phase 2 enzyme modulation will be conducted. Dose associated toxicities will be identified.

将在大鼠中进行一项为期14天的经口剂量范围探索研究， 确定1，2-二硫醇-3-巯基丙酸的剂量限制毒性。 终点将包括行为评估、食物和水 消耗，临床和解剖病理学。 二十八 然后将在大鼠中进行每日重复给药经口给药研究， 狗 终点将包括食物和水的消耗，身体 体重、临床观察、心脏和眼科评估， 临床化学和血液学，血浆测试试剂水平， 尿液分析以及解剖和组织病理学。 生化 细胞色素P450同工酶和2相酶调节的评价 将进行。 将确定剂量相关毒性。