课题基金 / 基金详情

FOURTEEN DAY ORAL RANGEFINDING STUDY IN RATS AND DOGS AN

FOURTEEN DAY ORAL RANGEFINDING STUDY IN RATS AND DOGS AN
大鼠和狗十四天口腔测距研究
批准号：
6365498
负责人：
BARRY S LEVINE
金额：
$0.0万
依托单位：
UNIVERSITY OF ILLINOIS AT CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
1999
资助国家：
美国
项目状态：
已结题
起止时间：
1999-09-30 至 2001-09-29
来源：
https://reporter.nih.gov/project-details/6365498
关键词：
behavior test clinical chemistry cytochrome P450 dogs dosage drug adverse effect drug screening /evaluation histology laboratory rat oral administration ribonucleotide reductase stilbenes toxicology

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中文摘要
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英文摘要
A 14-day, oral rangefinding study will be conducted in rats and dogs to identify the dose limiting toxicities of resveratrol. Endpoints will include behavioral assessment, food & water consumption, and clinical and anatomical pathology. Twenty-eight day, repeat-dose, oral studies will then be conducted in rats and dogs. Endpoints will include food and water consumption, body weight, clinical observation, cardiac and ophthalmic assessment, clinical chemistry and hematology, plasma test agent levels, urinalysis, and anatomic and histologic pathology. Biochemical evaluation of cytochrome P450 isoenzyme and phase 2 enzyme modulation will be conducted. Dose associated toxicities will be identified.
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