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PHARMACOKINETIC & TISSUE DISTRIBUTION OF C14-LYCOPENE

PHARMACOKINETIC & TISSUE DISTRIBUTION OF C14-LYCOPENE
药代动力学
批准号：
6358815
负责人：
BARRY S LEVINE
金额：
$0.0万
依托单位：
UNIVERSITY OF ILLINOIS AT CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-09-30 至 2001-05-29
来源：
https://reporter.nih.gov/project-details/6358815
关键词：
antineoplastics cancer prevention carbon carcinogenesis inhibitor carotenoids chemoprevention dogs drug metabolism drug screening /evaluation intravenous administration pharmacokinetics radionuclides radiopharmacology

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中文摘要
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英文摘要
The pharmacokinetics of carbon 14-labeled lycopene will be evaluated in dogs after single, intravenous administration. Dose administration with unlabeled compound will continue for 1 month after which another pharmacokinetic evaluation by intravenous administration will be evaluated. In addition, principle metabolites of the parent compound and the tissue distribution will be evaluated.
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FOURTEEN DAY ORAL RANGEFINDING STUDIES AND TWENTY-EIGHT
TOXICOLOGICAL EVALUATIONS OF POTENTIAL MEDICATIONS TO
FOURTEEN DAY ORAL RANGEFINDING STUDY IN RATS AND DOGS AN
TOXICOLOGICAL EVALUATIONS OF POTENTIAL MEDICATIONS TO
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