TOXICOLOGICAL EVALUATIONS OF POTENTIAL MEDICATIONS TO

潜在药物的毒理学评价

• 批准号: 6158417
• 负责人: BARRY S LEVINE
• 金额: $ 25万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-30 至 2003-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6158417
• 关键词: Primates; Rodentias; dogs; dosage; drug adverse effect; drug screening /evaluation; gastrointestinal motility /pressure; kidney function; toxicology

The contract will include evaluations of the compound's acute and repeat dose toxicity in rodents, dogs and/or primates. In addition, studies to determine the compound's effect on GI motility and renal function, and the compound's genotoxicity may also be conducted. The evaluations of safety/toxicity of drugs will be conducted under the GLP regulations of the FDA.

该合同将包括对该化合物在啮齿动物、狗和/或灵长类动物中的急性和重复剂量毒性的评估。 此外，还可以进行确定化合物对GI运动和肾功能的影响以及化合物遗传毒性的研究。 药物的安全性/毒性评价将根据FDA的GLP法规进行。