B CELL ANTIGEN RECEPTOR ACTIVATION OF ANTIGEN PROCESSING

描述（改编自研究者摘要）：B细胞抗原 受体（BCR）增强抗原向T细胞的呈递， 1000-部分地通过将抗原递送至细胞内的特定隔室而折叠 在该细胞中，其被加工以加载到MHC II类上。 一个新 鉴定细胞内结构，抗原受体诱导亚细胞 在小鼠B细胞系中，在抗原受体 (BCR)订婚 首席研究员和他的同事建议 （1）ARISC对于BCR促进的 2）ARISC是一种或多种信号的结果， 来自BCR，这些相同的途径被Nef利用。 蛋白 这些假设将在以下目标中得到检验：1） ARISC并建立其在体内的意义; 2）阐明ARISC的信号传导 参与ARISC形成的机制。

DESCRIPTION (Adapted from the Investigator's Abstract): The B cell antigen receptor (BCR) enhances the presentation of antigen to T cells over 1000-fold by, in part, delivering antigen to specific compartment(s) within the cell where it is processed for loading onto MHC class II. A newly identified intracellular structure, antigen receptor induced subcellular complex (ARISC), is seen in a mouse B cell line following antigen receptor (BCR) engagement. The principal investigator and his colleagues propose that: 1) The ARISC is necessary for the BCR facilitated presentation of some antigens and 2) The ARISC is a consequence of one or more signals that emanate from the BCR and that these same pathways are utilized by the Nef protein. These hypotheses will be tested in the aims 1) Characterize the ARISC and establish its significance in vivo, and 2) Elucidate the signaling mechanisms involved in ARISC formation.