VOLATILE ANESTHETICS AND CEREBRAL BLOOD FLOW REGULATION

挥发性麻醉剂与脑血流调节

• 批准号: 6019346
• 负责人: Anthony George Hudetz
• 金额: $ 19.96万
• 依托单位: MEDICAL COLLEGE OF WISCONSIN
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-08-01 至 2001-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6019346
• 关键词: blood flow measurement; cardiovascular pharmacology; cerebrovascular system; enzyme activity; gamma aminobutyrate; genetically modified animals; halothane; isoflurane; isozymes; laboratory mouse; nitric oxide; nitric oxide synthase; reactive hyperemia; vasodilation

DESCRIPTION: These studies will address how volatile anesthetics influence cerebral blood flow regulation. The first hypothesis is that differences in the hyperemic effects of various volatile anesthetics in specific brain regions are due to their different effects on regional neuronal activity which is coupled to the microvascular dilatation. They will determine the concentration-dependent and region-specific effects of three volatile anesthetics (halothane, isoflurane, and sevoflurane) on cerebrocortical microvascular perfusion and intraparenchymal microvessel diameter. They will determine if the relative degree of microvascular dilatation is dependent on the presence of spontaneous neuronal activity. The second hypothesis is that neuronal-derived NO plays an essential role in volatile anesthetic-induced microvascular dilation and hyperemia and that the anesthetic agent- and region-specific differences in these responses are in part neuronal NO-mediated. They will determine if neuronal and/or endothelial-derived NO modulate the differential, concentration-dependent responses of the cerebral microcirculation. The third hypothesis is that volatile anesthetic-induced vasodilatation is modulated by the anesthetic depression of spontaneous neuronal activity via enhancement of GABAergic effects and decreased production of NO. They will determine if regional and agent-specific differences in microvascular vasodilation in response to volatile anesthetics are due to the effects of these agents on the GABA and NO neuronal systems.

这些研究将探讨挥发性麻醉剂的影响