Neuroimaging of Anesthetic Modulation of Human Consciousness
人类意识麻醉调节的神经影像学
基本信息
- 批准号:10188553
- 负责人:
- 金额:$ 34.06万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2013
- 资助国家:美国
- 起止时间:2013-07-10 至 2023-04-30
- 项目状态:已结题
- 来源:
- 关键词:Anesthesia proceduresAnestheticsAttentionAwardBehavioralBiological ModelsBrainBrain imagingBrain regionClinicalClinical assessmentsCognitionCognitiveCommunicationComplexConsciousConsciousness DisordersDexmedetomidineEventFailureFirst Independent Research Support and Transition AwardsFunctional Magnetic Resonance ImagingFutureGeneral AnesthesiaGeneral anesthetic drugsGoalsHumanInvestigationKnowledgeLinkLocked-In SyndromeMeasuresMonitorMotorMusicNational Institute of General Medical SciencesNeurologicNeuronsOperative Surgical ProceduresParticipantPatientsPerceptionPerceptual disturbancePharmaceutical PreparationsPharmacologyPlayProcessPropofolProtocols documentationPsyche structureReproducibilityResearch Project GrantsResidual stateRestSedation procedureSensorySignal TransductionSpeedStimulusStrokeStructureSystemTennisTestingThinkingTimeUnconscious StateValidationVolitionWorkbasebehavioral responseblood oxygen level dependentbrain computer interfaceclinical practicecognitive functioncognitive taskcognitive testingexecutive functionexperiencehealthy volunteerinformation processinginsightmental imageryneural correlateneuroimagingnovelnovel strategiespredictive modelingrelating to nervous systemresponsesedativesensory inputsensory stimulussuccesssupport networktoolway finding
项目摘要
PROJECT SUMMARY / ABSTRACT
The overall goal of our work is to better understand the systems-level neuronal mechanisms by which general
anesthetics produce loss of consciousness. Our general hypothesis has been that anesthetics suppress
consciousness by disrupting the functioning of large-scale brain networks that support information integration
in the brain. The specific aims of the present proposal significantly advance and expand, both conceptually
and experimentally, our work conducted during the period of the first award. Specifically, we intend to test if
sedated participants who no longer respond behaviorally to spoken command are still able to perceive
and understand environmental signals and volitionally control their mentation in a task-related manner. We
will test this hypothesis by functional magnetic resonance imaging (fMRI) applied to assess the healthy
participants' (healthy volunteers) ability to generate willful, neuroanatomically specific, blood-oxygen-level
dependent (BOLD) responses during two established mental-imagery tasks (playing tennis and spatial
navigation). We hypothesize that under specific conditions of sedation, subjects will retain their capacity
for mental imagery despite their failure to initiate an overt response. If so, then the new findings may induce
a paradigm shift in the clinical assessment of consciousness in anesthesia. They would also establish
validation for monitoring disorders of consciousness and establish generality of the finding between
disorders of consciousness and general anesthesia. As a second aim, we intend to determine for the
first time, the neural conditions for the participants' ability for volitional mental imagery. We hypothesize
that spontaneous fluctuations of brain states during sedation directly influence and predict the participants'
ability for mental imagery. If confirmed, this would imply a novel causal link between the state of intrinsic
network activity and volitional mental activity in reduced states of consciousness. This would have
extremely important translational significance for optimizing brain-computer interfaces for the aid of
patients with behavioral compromise or reduced consciousness. Finally, in a third aim, we will determine the
neural correlates of distorted perception under sedation using complex, temporally structured stimuli such as
music. The latter studies should yield insight into how sedation may alter the temporal integration of complex
stimuli supporting conscious experience. Taken together, the project should significantly advance our
understanding of the fundamental neuronal mechanisms of anesthetic modulation of conscious
cognition with a significant translational and paradigmatic impact for the clinical assessment of the
state of consciousness and for the potential communication of patients via volitional mental activity.
项目摘要/摘要
我们工作的总体目标是更好地理解系统级神经元机制,通过这些机制,一般
麻醉剂会导致意识丧失。我们的普遍假设是麻醉剂抑制了
通过扰乱支持信息整合的大规模大脑网络的功能来实现意识
在大脑里。本提案的具体目标在概念上大大推进和扩大
在实验上,我们的工作是在一等奖期间进行的。具体地说,我们打算测试
不再对口头命令做出行为反应的服用镇静剂的参与者仍然能够感知
理解环境信号,并以与任务相关的方式有意识地控制它们的心理状态。我们
将通过应用功能磁共振成像(FMRI)来验证这一假设,以评估健康
参与者(健康志愿者)产生任性的、神经解剖学上特定的、血氧水平的能力
在两个既定的心理想象任务(打网球和空间)中的依赖(大胆)反应
导航)。我们假设,在特定的镇静条件下,受试者将保持他们的能力
尽管他们未能发起公开的反应,但他们仍然需要心理意象。如果是这样,那么新的发现可能会导致
麻醉中意识的临床评估的范式转变。他们还将建立
监测意识障碍的有效性和建立发现的普遍性之间的关系
意识障碍和全身麻醉。作为第二个目标,我们打算为
第一次,研究了受试者意志性心理表象能力的神经条件。我们假设
镇静期间大脑状态的自发波动直接影响和预测参与者的
心理表象的能力。如果得到证实,这将意味着内在状态之间存在一种新的因果联系
意识减退状态下的网络活动和意志性心理活动。如果是这样的话
优化脑机接口的极其重要的翻译意义
行为妥协或意识减退的患者。最后,在第三个目标中,我们将确定
使用复杂的、时间结构的刺激,例如镇静状态下,扭曲知觉的神经相关性
音乐。后一项研究应该能洞察镇静如何改变复合体的时间整合
支持有意识体验的刺激。综上所述,该项目应该会大大推进我们的
对麻醉调节意识的基本神经机制的认识
具有显著翻译和聚合影响的认知对临床评估的影响
意识状态和患者通过意志性心理活动进行潜在交流的能力。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Anthony George Hudetz其他文献
Anthony George Hudetz的其他文献
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{{ truncateString('Anthony George Hudetz', 18)}}的其他基金
Neuroimaging of Anesthetic Modulation of Human Consciousness
人类意识麻醉调节的神经影像学
- 批准号:
8577913 - 财政年份:2013
- 资助金额:
$ 34.06万 - 项目类别:
Neuroimaging of Anesthetic Modulation of Human Consciousness
人类意识麻醉调节的神经影像学
- 批准号:
8698776 - 财政年份:2013
- 资助金额:
$ 34.06万 - 项目类别:
Neuroimaging of Anesthetic Modulation of Human Consciousness
人类意识麻醉调节的神经影像学
- 批准号:
8825523 - 财政年份:2013
- 资助金额:
$ 34.06万 - 项目类别:
Neuroimaging of Anesthetic Modulation of Human Consciousness
人类意识麻醉调节的神经影像学
- 批准号:
9033919 - 财政年份:2013
- 资助金额:
$ 34.06万 - 项目类别:
Neuroimaging of Anesthetic Modulation of Human Consciousness
人类意识麻醉调节的神经影像学
- 批准号:
9920153 - 财政年份:2013
- 资助金额:
$ 34.06万 - 项目类别:
Neuroimaging of Anesthetic Modulation of Human Consciousness
人类意识麻醉调节的神经影像学
- 批准号:
9075170 - 财政年份:2013
- 资助金额:
$ 34.06万 - 项目类别:
VOLATILE ANESTHETICS AND CEREBRAL BLOOD FLOW REGULATION
挥发性麻醉剂与脑血流调节
- 批准号:
6019346 - 财政年份:1997
- 资助金额:
$ 34.06万 - 项目类别:
General Anesthetics and Cerebral Cortical Sensory Integration
全身麻醉与大脑皮层感觉统合
- 批准号:
10206336 - 财政年份:1997
- 资助金额:
$ 34.06万 - 项目类别:
General Anesthetics and Cerebral Cortical Sensory Integration
全身麻醉与大脑皮层感觉统合
- 批准号:
8609575 - 财政年份:1997
- 资助金额:
$ 34.06万 - 项目类别:
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