Neuroimaging of Anesthetic Modulation of Human Consciousness

人类意识麻醉调节的神经影像学

• 批准号: 9920153
• 负责人: Anthony George Hudetz
• 金额: $ 34.06万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-07-10 至 2022-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9920153
• 关键词: Anesthesia procedures; Anesthetics; Attention; Award; Behavioral; Biological Models; Brain; Brain imaging; Brain region; Clinical; Clinical assessments; Cognition; Cognitive; Communication; Complex; Conscious; Consciousness Disorders; Dexmedetomidine; Event; Failure; First Independent Research Support and Transition Awards; Functional Magnetic Resonance Imaging; Future; General Anesthesia; General anesthetic drugs; Goals; Human; Investigation; Knowledge; Link; Locked-In Syndrome; Measures; Monitor; Motor; Music; National Institute of General Medical Sciences; Neurologic; Neurons; Operative Surgical Procedures; Participant; Patients; Perception; Perceptual disturbance; Pharmaceutical Preparations; Pharmacology; Play; Process; Propofol; Protocols documentation; Psyche structure; Reproducibility; Research Project Grants; Residual state; Rest; Sedation procedure; Sensory; Signal Transduction; Speed; Stimulus; Stroke; Structure; System; Tennis; Testing; Thinking; Time; Unconscious State; Validation; Volition; Work; base; behavioral response; blood oxygen level dependent; brain computer interface; clinical practice; cognitive function; cognitive task; cognitive testing; executive function; experience; healthy volunteer; information processing; insight; mental imagery; neural correlate; neuroimaging; novel; novel strategies; predictive modeling; relating to nervous system; response; sedative; sensory input; sensory stimulus; success; support network; tool; way finding

PROJECT SUMMARY / ABSTRACT The overall goal of our work is to better understand the systems-level neuronal mechanisms by which general anesthetics produce loss of consciousness. Our general hypothesis has been that anesthetics suppress consciousness by disrupting the functioning of large-scale brain networks that support information integration in the brain. The specific aims of the present proposal significantly advance and expand, both conceptually and experimentally, our work conducted during the period of the first award. Specifically, we intend to test if sedated participants who no longer respond behaviorally to spoken command are still able to perceive and understand environmental signals and volitionally control their mentation in a task-related manner. We will test this hypothesis by functional magnetic resonance imaging (fMRI) applied to assess the healthy participants' (healthy volunteers) ability to generate willful, neuroanatomically specific, blood-oxygen-level dependent (BOLD) responses during two established mental-imagery tasks (playing tennis and spatial navigation). We hypothesize that under specific conditions of sedation, subjects will retain their capacity for mental imagery despite their failure to initiate an overt response. If so, then the new findings may induce a paradigm shift in the clinical assessment of consciousness in anesthesia. They would also establish validation for monitoring disorders of consciousness and establish generality of the finding between disorders of consciousness and general anesthesia. As a second aim, we intend to determine for the first time, the neural conditions for the participants' ability for volitional mental imagery. We hypothesize that spontaneous fluctuations of brain states during sedation directly influence and predict the participants' ability for mental imagery. If confirmed, this would imply a novel causal link between the state of intrinsic network activity and volitional mental activity in reduced states of consciousness. This would have extremely important translational significance for optimizing brain-computer interfaces for the aid of patients with behavioral compromise or reduced consciousness. Finally, in a third aim, we will determine the neural correlates of distorted perception under sedation using complex, temporally structured stimuli such as music. The latter studies should yield insight into how sedation may alter the temporal integration of complex stimuli supporting conscious experience. Taken together, the project should significantly advance our understanding of the fundamental neuronal mechanisms of anesthetic modulation of conscious cognition with a significant translational and paradigmatic impact for the clinical assessment of the state of consciousness and for the potential communication of patients via volitional mental activity.

项目总结/摘要 我们工作的总体目标是更好地理解系统水平的神经机制， 麻醉剂使人失去知觉。我们的假设是麻醉剂抑制了 通过破坏支持信息整合的大规模大脑网络的功能来破坏意识 在大脑中。本提案的具体目标在概念上大大推进和扩大了 和实验，我们的工作进行期间的第一个奖项。具体来说，我们打算测试， 不再对口头命令做出行为反应的镇静参与者仍然能够感知 并理解环境信号，并以与任务相关的方式有意识地控制它们的心理状态。我们 我将通过功能性磁共振成像（fMRI）来测试这一假设， 参与者（健康志愿者）产生故意的、神经解剖学特异性的血氧水平的能力 依赖（BOLD）反应在两个既定的心理意象任务（打网球和空间 导航）。我们假设，在特定的镇静条件下，受试者将保留他们的能力， 尽管他们无法做出明显的反应。如果是这样，那么新的发现可能会导致 麻醉中意识临床评估的范式转变。他们还将建立 确认监测意识障碍，并确定发现之间的一般性 意识障碍和全身麻醉。作为第二个目标，我们打算确定 第一次，被试意志心象能力的神经条件。我们假设 镇静期间大脑状态的自发波动直接影响并预测参与者的情绪。 心理意象的能力。如果得到证实，这将意味着一个新的因果关系之间的内在状态， 网络活动和意志心理活动在减少的意识状态。这将 对于优化脑机接口， 行为妥协或意识减退的患者。最后，在第三个目标中，我们将确定 在镇静状态下，使用复杂的、时间结构化的刺激， 音乐.后一项研究应该深入了解镇静如何改变复杂的时间整合。 支持意识体验的刺激。总的来说，该项目将大大促进我们的 了解麻醉调制意识的基本神经机制 认知具有重大的翻译和范式影响的临床评估 意识状态和患者通过意志心理活动的潜在交流。