MR DIAGNOSIS OF MUSCLE METABOLISM AND FUNCTION
MR DIAGNOSIS OF MUSCLE METABOLISM AND FUNCTION
批准号:
2871609
负责人:
Martin J Kushmerick
金额:
$45.63万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1993
资助国家:
美国
项目状态:
已结题
起止时间:
1993-02-01 至 2003-01-31
关键词:
adenosine triphosphate adenosinetriphosphatase bioenergetics blood flow measurement chromium clinical research congestive heart failure diagnosis design /evaluation electromyography exercise glycogenolysis human subject hydrogen ions insulin dependent diabetes mellitus muscle contraction muscle disorder diagnosis muscle function muscle metabolism myoglobin nuclear magnetic resonance spectroscopy oxidative phosphorylation oxygen perfusion
中文摘要
描述:该项目的目标是开发诊断程序
用31-P/1-H核磁共振波谱和1-H核磁共振对人体肌肉功能的影响
成像与能量平衡原理一起在第一个
授权期。申请者工作假说是
能量平衡提供了定义正常所必需的机械性信息
并解释完好无损的人体四肢的异常肌肉功能。这个
前三个具体目标发展了综合质量的概念和
能量平衡。聚合酶链式反应含量衡量供需平衡
肌肉ATPase和氧化磷酸化。肌红蛋白脱饱和度
衡量氧化磷酸化和氧化磷酸化之间的供需平衡
肌肉灌流。细胞内pH和乳酸测量两者之间的平衡
净糖酵解通量和灌流洗脱。中国的收缩经济
人类四肢肌肉将通过对ATPase的特性进行量化,因为
肌纤维力的产生和兴奋-收缩耦合。
运动时的聚合酶链式反应水平是否是局部灌注量与氧分压的联系
需求将受到测试,其规模和时间进程
运动中的糖原分解流量将被量化。第四个具体问题
AIM将调查一个或多个失衡的两个临床问题
肌肉能量学的组成部分。充血性心力衰竭患者
将调查ATP、H和氧平衡的异常以及患者
1型糖尿病患者将在异常情况下进行权衡
导致肌肉功能降低,但接近正常的整合
能量学。
英文摘要
DESCRIPTION: The goal of this project is to develop diagnostic procedures
for human muscle function using 31-P/1-H NMR spectroscopy and 1-H NMR
imaging together with principles of energy balance developed in the first
grant period. The applicants working hypothesis is that integration of
energy balance provides mechanistic information essential to define normal
and to interpret abnormal muscle function in the intact human limb. The
first three specific aims develop the notions of an integrative mass and
energy balance. PCr content measures the supply-demand balance between
muscle ATPases and oxidative phosphorylation. Myoglobin desaturation
measures the supply-demand balance between oxidative phosphorylation and
muscle perfusion. Intracellular pH and lactate measures the balance between
net glycolytic flux and washout by perfusion. The contractile economy in
human limb muscles will be quantified by characterizing the ATPase due to
myofibrillar force generation and to excitation-contraction coupling.
Whether PCr level during exercise is the link between local perfusion and O2
demand will be tested and the magnitude and time course of the
glycogenolytic flux during exercise will be quantified. The fourth specific
aim will probe two clinical problems for imbalances in one or more
components of muscle energetics. Patients with congestive heart failure
will be probed for abnormalities in ATP, H+ and oxygen balances and patients
with type 1 diabetes will be probed for a trade-off in abnormalities
resulting in lower functional, but near-normal integration of muscle
energetics.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Bruker Avance III 600 MHz (14T) Wide Bore Spectrometer
-
批准号:7840575
-
项目类别:
-
资助金额:$101.5万
-
财政年份:2010
-
负责人:Martin J Kushmerick
-
依托单位:
GRADIENT AND RF COIL UPGRADES FOR 47 T IMAGING SPECTROMETER
-
批准号:7335280
-
项目类别:
-
资助金额:$12.46万
-
财政年份:2006
-
负责人:Martin J Kushmerick
-
依托单位:
GRADIENT AND RF COIL UPGRADES FOR 47 T IMAGING SPECTROMETER: CANCER
-
批准号:7335278
-
项目类别:
-
资助金额:$4.67万
-
财政年份:2006
-
负责人:Martin J Kushmerick
-
依托单位:
Gradient and RF Coil Upgrades for 4.7 T Imaging Spectrometer
-
批准号:7046524
-
项目类别:
-
资助金额:$31.16万
-
财政年份:2006
-
负责人:Martin J Kushmerick
-
依托单位:
GRADIENT AND RF COIL UPGRADES FOR 47 T IMAGING SPECTROMETER: MUSCLE
-
批准号:7335277
-
项目类别:
-
资助金额:$10.9万
-
财政年份:2006
-
负责人:Martin J Kushmerick
-
依托单位:
GRADIENT AND RF COIL UPGRADES FOR 47 T IMAGING SPECTROMETER: DIET & OBESITY
-
批准号:7335279
-
项目类别:
-
资助金额:$3.12万
-
财政年份:2006
-
负责人:Martin J Kushmerick
-
依托单位:
Console upgrade for 4.7T Imaging and Spectroscopy System
-
批准号:6441148
-
项目类别:
-
资助金额:$50.0万
-
财政年份:2002
-
负责人:Martin J Kushmerick
-
依托单位:
MODEL OF INTRACELLULAR BIOENERGETICS & ENERGY BALANCE
-
批准号:6119764
-
项目类别:
-
资助金额:$0.0万
-
财政年份:1998
-
负责人:Martin J Kushmerick
-
依托单位:
UPGRADE OF 47T IMAGING AND SPECTROSCOPY SYSTEM
-
批准号:2503122
-
项目类别:
-
资助金额:$12.12万
-
财政年份:1998
-
负责人:Martin J Kushmerick
-
依托单位:
MR DIAGNOSIS OF MUSCLE METABOLISM AND FUNCTION
-
批准号:2643348
-
项目类别:
-
资助金额:$3.1万
-
财政年份:1993
-
负责人:Martin J Kushmerick
-
依托单位:
MR DIAGNOSIS OF HUMAN MUSCLE METABOLISM AND FUNCTION
-
批准号:3162357
-
项目类别:
-
资助金额:$29.91万
-
财政年份:1993
-
负责人:Martin J Kushmerick
-
依托单位:
MR DIAGNOSIS OF MUSCLE METABOLISM AND FUNCTION
-
批准号:6349947
-
项目类别:
-
资助金额:$44.46万
-
财政年份:1993
-
负责人:Martin J Kushmerick
-
依托单位:
MR & Optical Diagnosis of Mitochondrial Metabolism and Dysfunction
-
批准号:7590201
-
项目类别:
-
资助金额:$15.49万
-
财政年份:1993
-
负责人:Martin J Kushmerick
-
依托单位:
MR & Optical Diagnosis of Muscle Metabolism and Function
-
批准号:6863694
-
项目类别:
-
资助金额:$56.22万
-
财政年份:1993
-
负责人:Martin J Kushmerick
-
依托单位:
MR DIAGNOSIS OF MUSCLE METABOLISM AND FUNCTION
-
批准号:6149699
-
项目类别:
-
资助金额:$43.23万
-
财政年份:1993
-
负责人:Martin J Kushmerick
-
依托单位:
MR & Optical Diagnosis of Muscle Metabolism and Function
-
批准号:7026457
-
项目类别:
-
资助金额:$52.41万
-
财政年份:1993
-
负责人:Martin J Kushmerick
-
依托单位:
MR & Optical Diagnosis of Mitochondrial Metabolism and Dysfunction
-
批准号:7321432
-
项目类别:
-
资助金额:$50.43万
-
财政年份:1993
-
负责人:Martin J Kushmerick
-
依托单位:
MR DIAGNOSIS OF MUSCLE METABOLISM AND FUNCTION
-
批准号:2081120
-
项目类别:
-
资助金额:$28.26万
-
财政年份:1993
-
负责人:Martin J Kushmerick
-
依托单位:
MR DIAGNOSIS OF MUSCLE METABOLISM AND FUNCTION
-
批准号:2081119
-
项目类别:
-
资助金额:$31.52万
-
财政年份:1993
-
负责人:Martin J Kushmerick
-
依托单位:
MR & Optical Diagnosis of Muscle Metabolism and Function
-
批准号:6572860
-
项目类别:
-
资助金额:$55.33万
-
财政年份:1993
-
负责人:Martin J Kushmerick
-
依托单位:
海外基金