MODEL OF INTRACELLULAR BIOENERGETICS & ENERGY BALANCE
MODEL OF INTRACELLULAR BIOENERGETICS & ENERGY BALANCE
批准号:
6119764
负责人:
Martin J Kushmerick
金额:
$0.0万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1998
资助国家:
美国
项目状态:
已结题
起止时间:
1998-12-16 至 1999-11-30
中文摘要
肌肉提供了一个独特的机会,
生物能量和能量平衡系统。 本研究
在本资源中提供了一个特殊的机会来评估
细胞内化学通量的潜在机制,
方法结合实验和建模研究。 肌肉
系统的特点如下。 肌肉激活导致
细胞ATP酶的增加超过10倍,
静止状态 这种增加的ATP分解被ATP平衡
从收缩的代谢产物合成以及
激活信号(即,Ca++)。 这些信号激活线粒体
氧化磷酸化,这是主要过程(>95%)
驱动ATP的再合成以达到能量平衡。 我们
相关细胞内代谢物的测量提供了
对这些子系统如何组织的定量测试,
以达到能量平衡。 该项目将开发
定量模型
已知的酶和细胞器的特性和机制。 我们
实验系统提供了动力学和大小的测试,
这些模型预测的化学变化和通量。 结果
将是一个全面的细胞内能量学模型,
横纹肌的肌肉组织
英文摘要
Muscle provides a unique opportunity for quantifying a
bioenergetic and energy balance system in living tissue. This study
provides a special opportunity in this Resource to evaluate the
mechanisms underlying intracellular chemical fluxes using a parallel
approach combining experimental and modeling studies. The muscle
system can be characterized as follows. Muscle activation leads to
increase of cellular ATPases by more than 10-fold compared to the
resting state. This increased ATP breakdown is balanced by ATP
synthesis from the metabolic products of contraction as well as the
activation signal (i.e., Ca++). These signals activate mitochondrial
oxidative phosphorylation, which is the predominant process (>95%)
driving the ATP resynthesis needed to attain energy balance. Our
measurements of the relevant intracellular metabolites provide
quantitative tests of how these sub-systems are organized and
integrated to achieve energy balance. This project will develop
quantitative models based
on known enzyme and organelle properties and mechanisms. Our
experimental systems provide tests of the kinetics and magnitudes of
the chemical changes and fluxes predicted by these models. The result
will be a comprehensive model of intracellular energetics applicable
to striated muscle in general.
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会议论文
Bruker Avance III 600 MHz (14T) Wide Bore Spectrometer
-
批准号:7840575
-
项目类别:
-
资助金额:$101.5万
-
财政年份:2010
-
负责人:Martin J Kushmerick
-
依托单位:
GRADIENT AND RF COIL UPGRADES FOR 47 T IMAGING SPECTROMETER
-
批准号:7335280
-
项目类别:
-
资助金额:$12.46万
-
财政年份:2006
-
负责人:Martin J Kushmerick
-
依托单位:
GRADIENT AND RF COIL UPGRADES FOR 47 T IMAGING SPECTROMETER: CANCER
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批准号:7335278
-
项目类别:
-
资助金额:$4.67万
-
财政年份:2006
-
负责人:Martin J Kushmerick
-
依托单位:
Gradient and RF Coil Upgrades for 4.7 T Imaging Spectrometer
-
批准号:7046524
-
项目类别:
-
资助金额:$31.16万
-
财政年份:2006
-
负责人:Martin J Kushmerick
-
依托单位:
GRADIENT AND RF COIL UPGRADES FOR 47 T IMAGING SPECTROMETER: MUSCLE
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批准号:7335277
-
项目类别:
-
资助金额:$10.9万
-
财政年份:2006
-
负责人:Martin J Kushmerick
-
依托单位:
GRADIENT AND RF COIL UPGRADES FOR 47 T IMAGING SPECTROMETER: DIET & OBESITY
-
批准号:7335279
-
项目类别:
-
资助金额:$3.12万
-
财政年份:2006
-
负责人:Martin J Kushmerick
-
依托单位:
Console upgrade for 4.7T Imaging and Spectroscopy System
-
批准号:6441148
-
项目类别:
-
资助金额:$50.0万
-
财政年份:2002
-
负责人:Martin J Kushmerick
-
依托单位:
UPGRADE OF 47T IMAGING AND SPECTROSCOPY SYSTEM
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批准号:2503122
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项目类别:
-
资助金额:$12.12万
-
财政年份:1998
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负责人:Martin J Kushmerick
-
依托单位:
MR DIAGNOSIS OF MUSCLE METABOLISM AND FUNCTION
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批准号:2643348
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项目类别:
-
资助金额:$3.1万
-
财政年份:1993
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负责人:Martin J Kushmerick
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依托单位:
MR DIAGNOSIS OF HUMAN MUSCLE METABOLISM AND FUNCTION
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批准号:3162357
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项目类别:
-
资助金额:$29.91万
-
财政年份:1993
-
负责人:Martin J Kushmerick
-
依托单位:
MR DIAGNOSIS OF MUSCLE METABOLISM AND FUNCTION
-
批准号:6349947
-
项目类别:
-
资助金额:$44.46万
-
财政年份:1993
-
负责人:Martin J Kushmerick
-
依托单位:
MR & Optical Diagnosis of Mitochondrial Metabolism and Dysfunction
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批准号:7590201
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项目类别:
-
资助金额:$15.49万
-
财政年份:1993
-
负责人:Martin J Kushmerick
-
依托单位:
MR DIAGNOSIS OF MUSCLE METABOLISM AND FUNCTION
-
批准号:2871609
-
项目类别:
-
资助金额:$45.63万
-
财政年份:1993
-
负责人:Martin J Kushmerick
-
依托单位:
MR & Optical Diagnosis of Muscle Metabolism and Function
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批准号:6863694
-
项目类别:
-
资助金额:$56.22万
-
财政年份:1993
-
负责人:Martin J Kushmerick
-
依托单位:
MR DIAGNOSIS OF MUSCLE METABOLISM AND FUNCTION
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批准号:6149699
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项目类别:
-
资助金额:$43.23万
-
财政年份:1993
-
负责人:Martin J Kushmerick
-
依托单位:
MR & Optical Diagnosis of Muscle Metabolism and Function
-
批准号:7026457
-
项目类别:
-
资助金额:$52.41万
-
财政年份:1993
-
负责人:Martin J Kushmerick
-
依托单位:
MR & Optical Diagnosis of Mitochondrial Metabolism and Dysfunction
-
批准号:7321432
-
项目类别:
-
资助金额:$50.43万
-
财政年份:1993
-
负责人:Martin J Kushmerick
-
依托单位:
MR DIAGNOSIS OF MUSCLE METABOLISM AND FUNCTION
-
批准号:2081120
-
项目类别:
-
资助金额:$28.26万
-
财政年份:1993
-
负责人:Martin J Kushmerick
-
依托单位:
MR DIAGNOSIS OF MUSCLE METABOLISM AND FUNCTION
-
批准号:2081119
-
项目类别:
-
资助金额:$31.52万
-
财政年份:1993
-
负责人:Martin J Kushmerick
-
依托单位:
MR & Optical Diagnosis of Muscle Metabolism and Function
-
批准号:6572860
-
项目类别:
-
资助金额:$55.33万
-
财政年份:1993
-
负责人:Martin J Kushmerick
-
依托单位: