Console upgrade for 4.7T Imaging and Spectroscopy System

4.7T 成像和光谱系统控制台升级

• 批准号: 6441148
• 负责人: Martin J Kushmerick
• 金额: $ 50万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-03-15 至 2003-03-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6441148
• 关键词: biomedical equipment purchase; imaging /visualization /scanning; spectrometry

DESCRIPTION (provided by applicant): We are one of few research groups in the world with a high field system (4.7T) dedicated to human muscle research. Our track record of scientific advances establishes our preeminence for studies of muscle energetics, physiology, and metabolism in animal and human muscle with the goal of developing diagnostic methods for human diseases. New computer, software and radiofrequency (RF) electronic advances would make possible a wide range of new experimental approaches for NIH funded grants in our laboratory and for collaborating investigators. This application requests funds to purchase a new console and RF electronics to replace an 80?s vintage console. This out-dated console is hampering progress on current grants because of inadequate technology to push forward new advances. The new hardware and software will permit rapid shimming, improved signal to noise, interleaved acquisitions with different nuclei, and state-of-the-art imaging. We rely primarily on the use of surface coils and have serious limitations in digitizer memory and waveform generation for complex, gradient-enhanced, shaped-pulse sequences. The FASTMAP software in the new console will allow us to rapidly and reproducibly shim human limbs that are typically off center. This upgrade will also permit facile implementation of a state-of-the-art perfusion method, developed in our lab (FAWSETS), for local muscle blood flow measurements. The new RF electronics will permit multinuclear measurements of 1H and 31P for simultaneous interrogation of blood flow, ATP supply and demand, and metabolism. These measurements are currently possible only in serial experiments that double our experimental time and subject burden. Rapid scout imaging for checks on surface coil placement and state-of-the-art echo planar imaging to map the dynamics of muscle length changes during contraction are not possible now. The new console allowing coordinated control of the shims and gradients will permit implementation of state-of-the-art fast imaging programs needed for all projects. This upgrade will directly affect 5 NIH funded grants in Radiology and will assist in an additional 3 NIH grants outside the department, including 2 resource grants.

描述(申请人提供)：我们是世界上为数不多的研究小组之一。 世界上有一个致力于人体肌肉研究的高场系统(4.7吨)。我们的 科学进步的记录确立了我们在研究 动物和人类肌肉的肌肉能量学、生理学和新陈代谢 开发人类疾病诊断方法的目标。新电脑， 软件和射频(RF)电子技术的进步将使广泛的 美国国立卫生研究院资助助学金的一系列新的实验方法 以及合作调查人员。此应用程序请求资金以 购买一台新的游戏机和射频电子产品，以取代80英寸的S老式游戏机。 这个过时的控制台阻碍了当前拨款的进展，因为 技术不足，无法推动新的进步。新的硬件和 软件将允许快速垫片、改善信噪比、交错 不同核团的采集，以及最先进的成像技术。我们依赖于 主要是表面线圈的使用，在数字化仪上有严重的局限性 用于复杂的、梯度增强的整形脉冲的存储和波形生成 序列。新控制台中的FASTMAP软件将允许我们快速和 重复地填补通常偏离中心的人类四肢。此次升级将 还允许方便地实施最先进的灌流方法， 我们实验室开发的(FAWSETS)，用于局部肌肉血流量测量。这个 新的射频电子学将允许对1H和31P进行多核测量 同时询问血流量、ATP供需情况，以及 新陈代谢。这些测量目前只能以串行方式进行 使我们的实验时间和受试者负担增加一倍的实验。快速侦察 用于检查表面线圈放置和最先进的回声平面的成像 成像绘制收缩过程中肌肉长度变化的动态图并不是 现在有可能了。新的控制台允许协调控制垫片和 梯度将允许实施最先进的快速成像程序 所有项目都需要。这一升级将直接影响NIH资助的5项拨款 在放射学方面，并将在NIH以外的其他3个项目上提供援助 部门，包括2笔资源赠款。