PHASE SHIFTING AND SEDATIVE EFFECTS OF MELATONIN

该研究计划描述了测试不同特性的两项研究 人类的神经激素褪黑激素正在经历巨大的转变 睡眠-觉醒时间表。 第一个是实地研究以确定是否 适当定时服用褪黑激素可以帮助改变内部 昼夜节律起搏器可调整睡眠-觉醒时间表的 9 小时转变。 在此协议中，48 名受试者将经历 9 小时的提前或延迟 他们8天的睡眠-觉醒时间表。 受试者将被随机分配 在改变时间表的前 4 天服用安慰剂或褪黑激素。 将使用芯体的连续记录来测量相位 温度。在第二项研究中，我们将测试褪黑激素的功效 晚上工作后无需轮班即可改善白天睡眠 内源性昼夜节律阶段。 受试者（N = 10）将分别参加 褪黑激素试验和安慰剂试验。 经过一周的基线睡眠后， 受试者将来到实验室进行 2 个晚上的模拟夜间工作 接下来是白天的睡眠。 睡眠将被多导睡眠图记录 在 2 个基线晚上、2 天睡眠时段和 1 个恢复晚上。 在 此外，受试者将接受多次睡眠潜伏期测试 夜间工作期间的性能测试。

This research plan describes two studies that test different properties of the neurohormone melatonin in humans undergoing a large shift in their sleep-wake schedule. The first is a field study to determine whether appropriately-timed melatonin administration can help shift the internal circadian pacemaker to adjust to a 9-hr shift in the sleep-wake schedule. In this protocol, 48 subjects will undergo a 9-hr advance or delay in their sleep-wake schedule for 8 days. Subjects will be randomly assigned to take placebo or melatonin on the first 4 days of the shifted schedule. Phase will be measured using continuous recording of core body temperature. In the second study, we will test melatonin's efficacy in improving sleep during the day after night work without shifting endogenous circadian phase. Subjects (N=10) will each participate in a melatonin trial and a placebo trial. After a week of baseline sleep, subjects will come to the lab for 2 nights of simulated night work followed by daytime sleep. Sleep will be polysomnographically-recorded on 2 baseline nights, 2 day sleep episodes, and l recovery night. In addition, subjects will undergo Multiple Sleep Latency Tests and performance tests during the night work episodes.