PHASE SHIFTING AND SEDATIVE EFFECTS OF MELATONIN

这项研究计划描述了两项测试不同特性的研究 神经激素褪黑激素在人类体内发生了巨大的变化 睡眠-唤醒时间表。第一项是实地研究，以确定 适时服用褪黑素有助于转变体内 昼夜节律起搏器，以适应睡眠-觉醒时间表中9小时的变化。 在这项方案中，48名受试者将经历9小时的提前或延迟 他们的睡眠-醒来时间表为8天。受试者将被随机分配 在改变后的时间表的前4天服用安慰剂或褪黑素。 将使用核心体的连续记录来测量相位 温度。在第二项研究中，我们将测试褪黑素在 在晚间不倒班的工作后改善白天的睡眠 内生昼夜节律阶段。受试者(N=10)将各自参加一项 褪黑激素试验和安慰剂试验。在一周的基线睡眠后， 受试者将来实验室进行两个晚上的模拟夜间工作 然后是白天的睡眠。睡眠将被多导睡眠记录仪记录下来 治疗2个基线夜、2个日间睡眠发作、L康复夜。在……里面 此外，受试者将接受多次睡眠潜伏期测试和 在夜间工作时段进行性能测试。

This research plan describes two studies that test different properties of the neurohormone melatonin in humans undergoing a large shift in their sleep-wake schedule. The first is a field study to determine whether appropriately-timed melatonin administration can help shift the internal circadian pacemaker to adjust to a 9-hr shift in the sleep-wake schedule. In this protocol, 48 subjects will undergo a 9-hr advance or delay in their sleep-wake schedule for 8 days. Subjects will be randomly assigned to take placebo or melatonin on the first 4 days of the shifted schedule. Phase will be measured using continuous recording of core body temperature. In the second study, we will test melatonin's efficacy in improving sleep during the day after night work without shifting endogenous circadian phase. Subjects (N=10) will each participate in a melatonin trial and a placebo trial. After a week of baseline sleep, subjects will come to the lab for 2 nights of simulated night work followed by daytime sleep. Sleep will be polysomnographically-recorded on 2 baseline nights, 2 day sleep episodes, and l recovery night. In addition, subjects will undergo Multiple Sleep Latency Tests and performance tests during the night work episodes.