ESTABLISHMENT OF A BREEDING AND RESEARCH PROGRAM

建立育种和研究计划

• 批准号: 6155563
• 负责人: RONALD C COUCH
• 金额: $ 20万
• 依托单位: COULSTON FOUNDATION
• 依托单位国家: 美国
• 财政年份: 1986
• 资助国家: 美国
• 起止时间: 1986-09-30 至 2001-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6155563
• 关键词: Pan; animal breeding; animal care; animal colony; animal population genetics; clinical chemistry; histopathology; veterinary medicine

The Coulston Foundation proposes to continue a self-sustaining chimpanzee breeding colony of-animals which will produce 10-15 animals per year. Approximately 50% will he retained each year to serve as eventual breeders. The remaining infants will he provided to research programs of national importance. Two long-standing programs continue to support the offspring of this colony through governmental research efforts in Hepatitis at CDC, FDA, NIAID and AIDS vaccine development program with NCI and NIAID through Program Resources Institute. The 113 animals proposed include 65 confirmed breeders, 28 potential breeders. and 20 of other status. The consolidation of two primate facilities offers the influx of new genetic material into the NCBRP program by inclusion of breeders from the population housed at the La Velle facility and vice versa after appropriate screening. With the recommendation from the genetic consultants, this will maximize the genetic diversity of the entire inventory. Animals continue to be aggressively tested to ensure the animals are free from hepatitis. All the tests are currently being performed in-house; these include Hepatitis B, Hepatitis C antibody and PCR, liver enzyme assays, and when appropriate, liver biopsies, assuring a disease-free colony. A transition to a family group housing unit is planned to be completed in the next five years. Two populations will be maintained, formed from a genetic strategy provided, designating animals to either research and breeding pools, thus creating a purpose bred chimpanzee. Each family unit is provided an indoor/outdoor den (consisting of 6 animals) with access to play yards. The facilities supporting the remaining colony will undergo a renovation to enhance socialization expediting their move to the new facility as new buildings are built. Monies have been designated to renovate the isolettes with plans to expand BSL-3 experimental space to augment the current level of MDS vaccine research. Further congressional support is being sought to complete the remaining two phases that will complete the chimpanzee retirement housing and additional animal holding associated support areas (experimental and veterinary). Infants designated as breeding replacements will be left in family units as long as population dynamics allowing a comprehensive behavioral management program, multi-phasic in design, to incorporate plans for environmental enrichment, breeding, and normal sexual development. The project receives support by a talented group of experienced technicians and state-of-the-art clinical chemistry. hematology, microbiology, virology and immunology and pathology laboratories.

库尔斯顿基金会提议让一只能够自我维持的黑猩猩 繁育群体--每年可生产10-15只动物。 他每年将保留大约50%的股份作为最终的 饲养员。剩下的婴儿将被提供给 对国家的重要性。两个长期存在的计划继续支持 这个殖民地的后代通过政府的研究努力 美国疾病控制与预防中心、FDA、NIAID和艾滋病疫苗开发计划 NCI和NIAID通过计划资源研究所。 提议的113只动物包括65名已确认的饲养员，28名潜在饲养员 饲养员。其他身份的20人。两种灵长类动物的合并 设施为NCBRP提供新的遗传物质的流入 通过纳入来自洛杉矶种群的繁育者来实施计划 在适当的筛选后，VELL设备和反之亦然。与 来自遗传顾问的建议，这将使 整个物种的遗传多样性。 动物继续接受积极的测试，以确保动物是自由的 死于肝炎。所有测试目前都在内部进行； 这些包括乙肝、丙型肝炎抗体和聚合酶链式反应、肝酶 化验，并在适当的情况下，肝脏活检，确保没有疾病 殖民地。 计划完成向家庭集体住房单元的过渡 在接下来的五年里。将维持两个种群，由 一种提供的遗传策略，指定动物进行研究和 繁殖池，从而创造了一只专门繁殖的黑猩猩。每个家庭 单位设有室内/室外窝点(由6只动物组成) 进入游乐场。支持剩余殖民地的设施 将进行翻新以加强社会化，加快他们的行动 随着新建筑的建成，新设施将被转移到新设施。钱一直都是 指定翻新等值线，计划扩建BSL-3 提高当前MDS疫苗研究水平的实验空间。 目前正在寻求国会的进一步支持，以完成剩余的工作 两个阶段将完成黑猩猩退休住房和 额外的动物托举相关支撑区(试验区和 兽医)。被指定为繁殖替代者的婴儿将被留下来 在家庭单元中，只要人口动态允许全面 行为管理计划，多阶段设计，将 环境丰富、繁殖和正常性行为的计划 发展。 该项目得到了经验丰富的才华横溢的团队的支持 技术人员和最先进的临床化学。血液学， 微生物学、病毒学、免疫学和病理学实验室。