ESTABLISHMENT OF A BREEDING AND RESEARCH PROGRAM

建立育种和研究计划

• 批准号: 6085633
• 负责人: RONALD C COUCH
• 金额: $ 53.33万
• 依托单位: COULSTON FOUNDATION
• 依托单位国家: 美国
• 财政年份: 1986
• 资助国家: 美国
• 起止时间: 1986-09-30 至 2000-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6085633
• 关键词: Pan; animal breeding; animal care; animal colony; animal population genetics; clinical chemistry; histopathology; veterinary medicine

The Coulston Foundation proposes to continue a self-sustaining chimpanzee breeding colony of-animals which will produce 10-15 animals per year. Approximately 50% will he retained each year to serve as eventual breeders. The remaining infants will he provided to research programs of national importance. Two long-standing programs continue to support the offspring of this colony through governmental research efforts in Hepatitis at CDC, FDA, NIAID and AIDS vaccine development program with NCI and NIAID through Program Resources Institute. The 113 animals proposed include 65 confirmed breeders, 28 potential breeders. and 20 of other status. The consolidation of two primate facilities offers the influx of new genetic material into the NCBRP program by inclusion of breeders from the population housed at the La Velle facility and vice versa after appropriate screening. With the recommendation from the genetic consultants, this will maximize the genetic diversity of the entire inventory. Animals continue to be aggressively tested to ensure the animals are free from hepatitis. All the tests are currently being performed in-house; these include Hepatitis B, Hepatitis C antibody and PCR, liver enzyme assays, and when appropriate, liver biopsies, assuring a disease-free colony. A transition to a family group housing unit is planned to be completed in the next five years. Two populations will be maintained, formed from a genetic strategy provided, designating animals to either research and breeding pools, thus creating a purpose bred chimpanzee. Each family unit is provided an indoor/outdoor den (consisting of 6 animals) with access to play yards. The facilities supporting the remaining colony will undergo a renovation to enhance socialization expediting their move to the new facility as new buildings are built. Monies have been designated to renovate the isolettes with plans to expand BSL-3 experimental space to augment the current level of MDS vaccine research. Further congressional support is being sought to complete the remaining two phases that will complete the chimpanzee retirement housing and additional animal holding associated support areas (experimental and veterinary). Infants designated as breeding replacements will be left in family units as long as population dynamics allowing a comprehensive behavioral management program, multi-phasic in design, to incorporate plans for environmental enrichment, breeding, and normal sexual development. The project receives support by a talented group of experienced technicians and state-of-the-art clinical chemistry. hematology, microbiology, virology and immunology and pathology laboratories.

库尔斯顿基金会建议继续一个自给自足的黑猩猩 繁殖群的动物，将产生10-15动物每年。 每年将保留大约50%的资金， 饲养员剩下的婴儿将被提供给 国家重要性。两个长期计划继续支持 这个殖民地的后代通过政府的研究工作， CDC、FDA、NIAID和艾滋病疫苗开发计划中的肝炎， NCI和NIAID通过计划资源研究所。 提议的113只动物包括65只已确认的育种者，28只潜在的 饲养员其他身份的20人两种灵长类动物的合并 设施提供了新的遗传物质流入NCBRP 该计划通过纳入饲养员从人口安置在洛杉矶 在适当筛选后，Velle设施和反之亦然。与 遗传咨询师的建议，这将最大限度地提高 整个库存的遗传多样性。 动物继续受到积极的测试，以确保动物是免费的， 得了肝炎所有测试目前都在内部进行; 其中包括乙型肝炎B、丙型肝炎抗体和PCR、肝酶 化验，并在适当时，肝活检，确保无病 殖民地 计划完成向家庭集体住房单元的过渡 未来五年将保留两个种群，由 提供了一种遗传策略，指定动物进行研究， 繁殖池，从而创造了一个目的繁殖黑猩猩。每个家庭 单位提供了一个室内/室外巢穴（由6只动物组成）， 进入游乐场。支持剩余殖民地的设施 将进行改造，以提高社会化，加快他们的行动 随着新建筑的建成，款项已以 指定翻新isolettes与计划扩大BSL-3 实验空间，以提高目前的骨髓增生异常综合症疫苗研究水平。 正在寻求国会的进一步支持，以完成剩余的 这两个阶段将完成黑猩猩退休住房， 额外的动物保持相关的支持区域（实验和 兽医）。被指定为繁殖替代品的婴儿将被留下 只要人口动态允许全面的 行为管理计划，多阶段的设计， 环境富集、繁殖和正常性生活的计划 发展 该项目得到了一个有经验的人才团队的支持， 技术人员和最先进的临床化学。血液学， 微生物学、病毒学、免疫学和病理学实验室。