VITAMINS E/C & INCIDENT AD-BIRACIAL COMMUNITY STUDY

拟议的研究将评估总营养素摄入量与 抗氧化剂、维生素E和维生素C与阿尔茨海默氏症 在8330名65岁及以上的混血人口中发现疾病 生活在地理上限定的社区中。东波士顿研究 提供数据表明维生素E和维生素C的使用可能与 以降低发生阿尔茨海默病的风险。此外, 爱荷华州和东波士顿EPESE的初步数据似乎表明 维生素E的使用可能会导致认知障碍的下降较少 年龄。爱荷华州和东波士顿基于人口的纵向设计 研究表明，这一结果不太可能是由有偏见的估计造成的； 然而，这些数据仅限于目前维生素补充剂的使用情况和 补充剂使用者的数量有限。拟议的研究将 提供膳食总摄入量的基线信息以及当前 以及芝加哥健康杂志参与者过去服用维生素补充剂的情况 和老龄化项目。拟议的研究将检验以下假设： (A)临床诊断为阿尔茨海默病的发病率较低 维生素E摄入量较高的人群。(二)临床发病率 在摄入量较高的人中，诊断为阿尔茨海默病的比例较低 (C)维生素E和维生素C的摄入量与 认知功能下降。此外，这项研究将提供一个 确定的老年人群体的营养摄入量描述， 确定三年内营养素摄入量变化的预测因素， 并评估食物中营养估计的可靠性和有效性 频次问卷调查。拟议的研究包括三个部分： 1)营养素摄入量、认知功能和 芝加哥健康和老龄化中的其他协变量和流行疾病 项目，正在进行的基于人群的事件前瞻性研究 阿尔茨海默病，2)营养变化的随访评估 摄入量和认知功能，以及事件的临床评估 阿尔茨海默病从基线开始三年，以及3)进行 食物频度评估方法的信度和效度研究 芝加哥健康与老龄化项目人群的营养摄入量。

The proposed study will assess the relation between total nutrient intake of the antioxidants, vitamin E and vitamin C, and incident Alzheimer's disease in a bi-racial population of 8330 persons 65 years and older living in a geographically-defined community. The East Boston studies provide data suggesting that use of vitamin E and vitamin C may be related to decreased risk of incident Alzheimer's disease. In addition, preliminary data from the Iowa and East Boston EPESE appear to indicate that vitamin E use may result in less decline in cognitive impairment with age. The population-based, longitudinal design of the Iowa and East Boston studies make it unlikely that the results are due to biased estimates; however, the data were restricted to current vitamin supplement use and there were a limited number of supplement users. The proposed study will provide baseline information on total dietary intake as well as current and past use of vitamin supplements for participants in the Chicago Health and Aging Project. The proposed study will test the following hypotheses: (a) Incidence of clinically diagnosed Alzheimer's disease is lower among persons with higher intake of vitamin E. (b) Incidence of clinically diagnosed Alzheimer's disease is lower among persons with higher intake of vitamin C. (c) Intakes of vitamin E and vitamin C are inversely related to decline in cognitive function. In addition, the study will provide a description of nutrient intake in a defined population of older persons, identify predictors of change in nutrient intake over a three-year period, and assess the reliability and validity of nutrient estimates from a food frequency questionnaire. There are three components to the proposed study: 1) the baseline assessment of nutrient intake, cognitive function and other covariates, and prevalent disease in the Chicago Health and Aging Project, an on-going population-based prospective study of incident Alzheimer's disease, 2) the follow-up assessment of changes in nutrient intake and cognitive function, and clinical evaluation of incident Alzheimer's disease three years from baseline, and 3) the conduct of reliability and validity studies on the food frequency method of assessing nutrient intake in the Chicago Health and Aging Project population.