CON ON MOLECULAR MECHANISMS IN DNA REPLICATION AND RECOM

DNA 复制和重组的分子机制

• 批准号: 2744453
• 负责人: Jerard Hurwitz
• 金额: $ 0.9万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-02-01 至 2000-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2744453
• 关键词: DNA replication; genetic recombination; meeting /conference /symposium; molecular genetics

Many of the proteins involved in DNA replication and recombination in both prokaryotes and eukaryotes have been defined. Considerable conservation of these events has been noted over great evolutionary changes. In eukaryotes, origin activation has been shown to involve the origin recognition complex and a battery of other critical proteins that interact with the complex. In recombination, key steps in this process involve formation and processing of intermediates and resolution of joined molecules. The precise manner by which replication and recombination are initiated and subsequently controlled, however, remain unclear, as is the function of many of the key gene products. Furthermore, the realization that replication and recombination can be coupled has recently become evident, but the precise nature of that coordination is unknown. The goal of the meeting is to bring together investigators pursuing these problems at all levels (involving biochemistry, genetics and biophysics) to discuss recent advances. Such an exchange of information will permit an in depth evaluation of new directions that should prove fruitful for future research efforts. The Keystone Meeting on the Mechanism of DNA Replication and Recombination has been held every three years. It is the only meeting that is held which brings together scientists that share these common interests.

许多参与DNA复制和重组的蛋白质在 原核生物和真核生物都已被定义。相当可观 这些事件的保护已经被注意到超过了巨大的进化 改变。在真核生物中，起源激活已被证明涉及 来源识别复合体和一系列其他关键蛋白质 与情结互动。在重组中，这一过程中的关键步骤 涉及中间体的形成和加工以及对 联结的分子。复制和复制的精确方式 然而，重组被启动并随后受到控制 许多关键基因产物的功能也不清楚。 此外，意识到复制和重组可以 耦合最近变得很明显，但其确切的性质 协调性是未知的。 会议的目的是将调查人员聚集在一起，寻找 所有层面的这些问题(涉及生物化学、遗传学和 生物物理学)讨论最新进展。这样的信息交换 将允许对新方向进行深入评估，这些方向应该证明 为未来的研究努力取得了丰硕成果。Keystone会议上的 DNA复制和重组的机制每三年举行一次 好几年了。这是唯一一次聚集在一起的会议 拥有这些共同兴趣的科学家。