CON ON MOLECULAR MECHANISMS IN DNA REPLICATION AND RECOM

许多参与DNA复制和重组的蛋白质， 原核生物和真核生物都已被定义。 相当大 这些事件的保存已经注意到了巨大的进化 变化 在真核生物中，起源激活已被证明涉及 起源识别复合物和一系列其他关键蛋白质， 与复杂的互动。 在重组过程中， 涉及中间体的形成和加工以及 连接的分子 复制的精确方式， 重组被启动并随后被控制，然而， 目前还不清楚，许多关键基因产物的功能也不清楚。 此外，实现复制和重组可以 耦合最近变得明显，但其确切性质 协调是未知的。 会议的目的是召集调查人员， 这些问题在各个层面（涉及生物化学，遗传学和 生物物理学）讨论最新进展。 这样的信息交流 将允许对新方向进行深入评估， 为今后的研究工作做出了贡献。 关键会议 DNA复制和降解的机制每三年举行一次 年这是唯一一次聚集了 有着共同兴趣的科学家。

Many of the proteins involved in DNA replication and recombination in both prokaryotes and eukaryotes have been defined. Considerable conservation of these events has been noted over great evolutionary changes. In eukaryotes, origin activation has been shown to involve the origin recognition complex and a battery of other critical proteins that interact with the complex. In recombination, key steps in this process involve formation and processing of intermediates and resolution of joined molecules. The precise manner by which replication and recombination are initiated and subsequently controlled, however, remain unclear, as is the function of many of the key gene products. Furthermore, the realization that replication and recombination can be coupled has recently become evident, but the precise nature of that coordination is unknown. The goal of the meeting is to bring together investigators pursuing these problems at all levels (involving biochemistry, genetics and biophysics) to discuss recent advances. Such an exchange of information will permit an in depth evaluation of new directions that should prove fruitful for future research efforts. The Keystone Meeting on the Mechanism of DNA Replication and Recombination has been held every three years. It is the only meeting that is held which brings together scientists that share these common interests.