ACETOGENIC AUTOTROPHY AND METABOLISM OF NICKEL

镍的乙酸自养和代谢

基本信息

  • 批准号:
    3070793
  • 负责人:
  • 金额:
    $ 5.02万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    1986
  • 资助国家:
    美国
  • 起止时间:
    1986-09-01 至 1991-08-31
  • 项目状态:
    已结题

项目摘要

Nickel is a biologically active trace metal important to mammalian health, as are numerous obligately anaerobic bacteria which inhabit the microintestinal environment. This study centers on further resolving (i) the biochemical/biological nature of nickel in acetogenic bacteria and (ii) the autotrophic metabolism of this biological group. Specifically, the biochemistry and physiological function of the nickel enzyme carbon monoxide dehydrogenase will be further resolved and acetogenic hydrogenase will be purified and characterized. The regulation and intracellular localization of autotrophic enzymes will be studied in effort to gain insights into their physiological roles. Antibodies (rabbit) against key catalysts may be used as specific probes to aid in this elucidation. 14C tracer and product profile analyses will be conducted to study whole cell carbon flow and energetics of autotrophic vs. heterotrophic growth. Additionally, studies on recently discovered nickel proteins will be initiated to ascertain their potential physiological functions. Defined minimal media developed for the cultivation of acetogenic bacteria will facilitate studies on acetogenic nickel transport and trace metal requirements. Since acetogens and most of their enzymes are extremely sensitive to oxidation, all cultivation, purification, and analytical procedures will be conducted under strict anaerobiosis.
镍是一种具有生物活性的微量金属,对哺乳动物的健康很重要,

项目成果

期刊论文数量(0)
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专利数量(0)

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HAROLD L DRAKE其他文献

HAROLD L DRAKE的其他文献

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{{ truncateString('HAROLD L DRAKE', 18)}}的其他基金

ACETOGENIC AUTOTROPHY AND METABOLISM OF NICKEL
镍的乙酸自养和代谢
  • 批准号:
    3070795
  • 财政年份:
    1986
  • 资助金额:
    $ 5.02万
  • 项目类别:
ACETOGENIC AUTOTROPHY AND METABOLISM OF NICKEL
镍的乙酸自养和代谢
  • 批准号:
    3070796
  • 财政年份:
    1986
  • 资助金额:
    $ 5.02万
  • 项目类别:
ACETOGENIC AUTOTROPHY AND METABOLISM OF NICKEL
镍的乙酸自养和代谢
  • 批准号:
    3070797
  • 财政年份:
    1986
  • 资助金额:
    $ 5.02万
  • 项目类别:
ACETOGENIC AUTOTROPHY AND METABOLISM OF NICKEL
镍的乙酸自养和代谢
  • 批准号:
    3070794
  • 财政年份:
    1986
  • 资助金额:
    $ 5.02万
  • 项目类别:
NICKEL AND ACETOGENIC AUTOTROPHIC METABOLISM
镍与乙酸自养代谢
  • 批准号:
    3132266
  • 财政年份:
    1984
  • 资助金额:
    $ 5.02万
  • 项目类别:
NICKEL AND ACETOGENIC AUTOTROPHIC METABOLISM
镍与乙酸自养代谢
  • 批准号:
    3132269
  • 财政年份:
    1984
  • 资助金额:
    $ 5.02万
  • 项目类别:
NICKEL AND ACETOGENIC AUTOTROPHIC METABOLISM
镍与乙酸自养代谢
  • 批准号:
    3132268
  • 财政年份:
    1984
  • 资助金额:
    $ 5.02万
  • 项目类别:
NICKEL AND ACETOGENIC AUTOTROPHIC METABOLISM
镍与乙酸自养代谢
  • 批准号:
    3132270
  • 财政年份:
    1984
  • 资助金额:
    $ 5.02万
  • 项目类别:
NICKEL AND ACETOGENIC AUTOTROPHIC METABOLISM
镍与乙酸自养代谢
  • 批准号:
    3132264
  • 财政年份:
    1984
  • 资助金额:
    $ 5.02万
  • 项目类别:
NICKEL AND ACETOGENIC AUTOTROPHIC METABOLISM
镍与乙酸自养代谢
  • 批准号:
    3132267
  • 财政年份:
    1984
  • 资助金额:
    $ 5.02万
  • 项目类别:

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