ACETOGENIC AUTOTROPHY AND METABOLISM OF NICKEL
镍的乙酸自养和代谢
基本信息
- 批准号:3070794
- 负责人:
- 金额:$ 5.27万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1986
- 资助国家:美国
- 起止时间:1986-09-01 至 1991-08-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Nickel is a biologically active trace metal important to mammalian health,
as are numerous obligately anaerobic bacteria which inhabit the
microintestinal environment. This study centers on further resolving (i)
the biochemical/biological nature of nickel in acetogenic bacteria and (ii)
the autotrophic metabolism of this biological group. Specifically, the
biochemistry and physiological function of the nickel enzyme carbon
monoxide dehydrogenase will be further resolved and acetogenic hydrogenase
will be purified and characterized. The regulation and intracellular
localization of autotrophic enzymes will be studied in effort to gain
insights into their physiological roles. Antibodies (rabbit) against key
catalysts may be used as specific probes to aid in this elucidation. 14C
tracer and product profile analyses will be conducted to study whole cell
carbon flow and energetics of autotrophic vs. heterotrophic growth.
Additionally, studies on recently discovered nickel proteins will be
initiated to ascertain their potential physiological functions. Defined
minimal media developed for the cultivation of acetogenic bacteria will
facilitate studies on acetogenic nickel transport and trace metal
requirements. Since acetogens and most of their enzymes are extremely
sensitive to oxidation, all cultivation, purification, and analytical
procedures will be conducted under strict anaerobiosis.
镍是一种具有生物活性的微量金属,对哺乳动物的健康很重要,
项目成果
期刊论文数量(0)
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