课题基金 / 基金详情

NICKEL AND ACETOGENIC AUTOTROPHIC METABOLISM

NICKEL AND ACETOGENIC AUTOTROPHIC METABOLISM
镍与乙酸自养代谢
批准号:
3132266
负责人:
HAROLD L DRAKE
金额:
$14.45万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1984
资助国家:
美国
项目状态:
已结题
起止时间:
1984-12-01 至 1991-06-30

项目摘要

项目成果

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相关文献

中文摘要
翻译
意义:产醋菌在发酵过程中起着重要的作用
英文摘要
Significance: Acetogenic bacteria play important roles in the flow of carbon and energy in anaerobic habitats, including the human gastrointestinal tract. The unique autotrophic pathway used by acetogens is termed the acetyl-CoA (or Wood) pathway, and studies have shown that acetogenesis is a fundamental biological process. New and diverse metabolic activities have recently been elucidated for acetogens, including the capacity to derive both carbon and energy from aromatic compounds. These potentials may contribute to the survival and interaction of acetogens in their native habitats. In general, the anaerobic metabolism of aromatic compounds is poorly defined, and the acetogenic metabolism of such substrates is likely coupled to the overall biotransformation of lignin and other aromatic substrates, including aromatic toxic wastes. Abstract of Research Plan: Strictly defined environments for resolution of the metabolic potentials of acetogenic bacteria have been developed, and new enzyme systems central to acetogenesis from aromatic compounds have been discovered. The main goal of this project will be to further resolve these newly realized catalytic activities. The classic acetogen Clostridium thermoaceticum, the human gastrointestinal isolate Peptostreptococcus productus, and other acetogens will be used in this study. Methods will include: enzyme analyses on the flow of carbon and reductant from aromatic compounds; 13C and 14C tracer analyses; high performance liquid chromatographic (HPLC) analyses; high-resolution fast protein liquid chromatography (FPLC) for the purification of enzyme systems; and the use of enzyme-specific antibodies as molecular probes and inhibitors. The specific aims include: (i) Resolving the specificity and diversity of new capacities observed for acetogenesis from aromatic compounds. (ii) Elucidating how carbon and reductant which are derived from aromatic substituent groups are utilized in the acetyl-CoA pathway. (iii) The purification and characterization of new enzyme systems involved in these processes.
期刊论文(13)
专著(0)
科研奖励(0)
会议论文
Energy-dependent transport of nickel by Clostridium pasteurianum.
巴氏梭菌对镍的能量依赖性运输。
DOI: 10.1128/jb.170.1.234-238.1988
发表时间: 1988
期刊: Journal of bacteriology
影响因子: 3.2
作者: [Bryson,MF, Drake,HL]
通讯作者: Drake,HL
Biotransformations of carboxylated aromatic compounds by the acetogen Clostridium thermoaceticum: generation of growth-supportive CO2 equivalents under CO2-limited conditions.
产乙酸菌热乙酸梭菌对羧化芳香族化合物的生物转化:在 CO2 限制条件下产生支持生长的 CO2 当量。
DOI: 10.1128/jb.172.1.212-217.1990
发表时间: 1990
期刊: Journal of bacteriology
影响因子: 3.2
作者: [Hsu,T, Daniel,SL, Lux,MF, Drake,HL]
通讯作者: Drake,HL
Carbon monoxide-dependent chemolithotrophic growth of Clostridium thermoautotrophicum.
热自养梭菌的一氧化碳依赖性化能自养生长。
DOI: 10.1128/aem.53.8.1902-1906.1987
发表时间: 1987
期刊: Applied and environmental microbiology
影响因子: 4.4
作者: [Savage,MD, Wu,ZG, Daniel,SL, LundieJr,LL, Drake,HL]
通讯作者: Drake,HL
Adaptation of the acetogen Clostridium thermoautotrophicum to minimal medium.
产乙酸菌热自养梭菌对基本培养基的适应。
DOI: 10.1128/jb.165.1.315-318.1986
发表时间: 1986
期刊: Journal of bacteriology
影响因子: 3.2
作者: [Savage,MD, Drake,HL]
通讯作者: Drake,HL
共 10 条
    ACETOGENIC AUTOTROPHY AND METABOLISM OF NICKEL
    • 批准号:
      3070795
    • 项目类别:
    • 资助金额:
      $5.12万
    • 财政年份:
      1986
    • 负责人:
      HAROLD L DRAKE
    • 依托单位:
    ACETOGENIC AUTOTROPHY AND METABOLISM OF NICKEL
    • 批准号:
      3070793
    • 项目类别:
    • 资助金额:
      $5.02万
    • 财政年份:
      1986
    • 负责人:
      HAROLD L DRAKE
    • 依托单位:
    ACETOGENIC AUTOTROPHY AND METABOLISM OF NICKEL
    • 批准号:
      3070796
    • 项目类别:
    • 资助金额:
      $5.12万
    • 财政年份:
      1986
    • 负责人:
      HAROLD L DRAKE
    • 依托单位:
    ACETOGENIC AUTOTROPHY AND METABOLISM OF NICKEL
    • 批准号:
      3070797
    • 项目类别:
    • 资助金额:
      $6.51万
    • 财政年份:
      1986
    • 负责人:
      HAROLD L DRAKE
    • 依托单位:
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