UPPER AIRWAY INFLUENCE ON CONTROL OF BREATHING

上呼吸道对呼吸控制的影响 被研究。 将特别强调上呼吸道压力 反射。 这种反射反应的几个方面将使用 气管造口、麻醉下的隔离上气道准备 动物 该反射反应的特异性将通过确定 上气道压力变化对呼吸活动的影响 各种上呼吸道肌肉 物种变异和成熟效应 也将研究反射反应。 上呼吸道的影响 吸气和呼气持续时间的压力变化以及 将详细研究对峰值药理活性的影响。 此外，喉机械感受器对上气道的反应 压力变化将被识别、定位， 记录在案。 外周切口单纤维的动作电位 将记录上级喉神经内分支的末端， 这个目的。 上述研究有望提供有价值的 对维持上呼吸道通畅以及 上呼吸道在呼吸控制中的作用。 此外，本发明还提供了一种方法， 这些研究被认为与我们对呼吸暂停的理解有关， 各种临床状态，如早产儿呼吸暂停、SIDS和睡眠 呼吸暂停

Influences originating from the upper airway on control of breathing will be studied. Special emphasis will be given to an upper airway pressure reflex. Several aspects of this reflex response will be studied using an isolated upper airway preparation in tracheostomized, anesthetized animals. Specificity of this reflex response will be tested by determining the effects of upper airway pressure changes on the respiratory activity of various upper airway muscles. Species variability and maturational effects of the reflex response will also be investigated. Effects of upper airway pressure changes on inspiratory and expiratory duration as well as the effect on peak diaphragmatic activity will be studied in detail. Additionally, laryngeal mechanoreceptors responding to upper airway pressure changes will be identified, localized and their responses documented. Action potentials from the single fibers of the peripheral cut end of the internal branch of superior laryngeal nerve will be recorded for this purpose. The above studies are anticipated to provide valuable insight into maintenance of upper airway patency as well as the contribution of upper airway in the control of breathing. In addition, these studies are viewed as relevant to our understanding of apnea seen in a variety of clinical states such as apnea of prematurity, SIDS and sleep apnea.