UPPER AIRWAY INFLUENCE ON CONTROL OF BREATHING

上呼吸道对呼吸控制的影响

• 批准号: 3081684
• 负责人: OOMMEN P MATHEW
• 金额: $ 6.31万
• 依托单位: UNIVERSITY OF TEXAS MED BR GALVESTON
• 依托单位国家: 美国
• 财政年份: 1983
• 资助国家: 美国
• 起止时间: 1983-07-01 至 1988-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3081684
• 关键词: action potentials; electromyography; larynx; mechanoreceptors; pulmonary respiration; pulmonary stretch receptors; respiratory airway pressure; respiratory muscles; respiratory reflex; tracheotomy

Influences originating from the upper airway on control of breathing will be studied. Special emphasis will be given to an upper airway pressure reflex. Several aspects of this reflex response will be studied using an isolated upper airway preparation in tracheostomized, anesthetized animals. Specificity of this reflex response will be tested by determining the effects of upper airway pressure changes on the respiratory activity of various upper airway muscles. Species variability and maturational effects of the reflex response will also be investigated. Effects of upper airway pressure changes on inspiratory and expiratory duration as well as the effect on peak diaphragmatic activity will be studied in detail. Additionally, laryngeal mechanoreceptors responding to upper airway pressure changes will be identified, localized and their responses documented. Action potentials from the single fibers of the peripheral cut end of the internal branch of superior laryngeal nerve will be recorded for this purpose. The above studies are anticipated to provide valuable insight into maintenance of upper airway patency as well as the contribution of upper airway in the control of breathing. In addition, these studies are viewed as relevant to our understanding of apnea seen in a variety of clinical states such as apnea of prematurity, SIDS and sleep apnea.

来自上呼吸道对呼吸控制的影响将 被研究。 将特别强调上呼吸道压力 反射。 将使用以下方法研究这种反射反应的几个方面： 气管切开、麻醉状态下的隔离上呼吸道准备 动物。 该反射反应的特异性将通过确定来测试 上呼吸道压力变化对呼吸活动的影响 各种上呼吸道肌肉。 物种变异和成熟效应 反射反应的情况也将被研究。 上呼吸道的影响 吸气和呼气持续时间以及压力变化 将详细研究对峰值膈肌活动的影响。 此外，喉部机械感受器对上呼吸道有反应 压力变化将被识别、定位及其响应 记录在案。 周边切口单纤维的动作电位 记录喉上神经内支末端 这个目的。 上述研究预计将提供有价值的 深入了解维持上呼吸道通畅以及 上呼吸道在呼吸控制中的作用。 此外， 这些研究被认为与我们对呼吸暂停的理解相关 各种临床状态，如早产儿呼吸暂停、SIDS 和睡眠 呼吸暂停。