CONTROL OF BREATHING: INFLUENCES OF UPPER AIRWAY ORIGIN
呼吸控制:上呼吸道起源的影响
基本信息
- 批准号:2217125
- 负责人:
- 金额:$ 10.97万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1984
- 资助国家:美国
- 起止时间:1984-08-01 至 1995-06-30
- 项目状态:已结题
- 来源:
- 关键词:apnea body temperature breast feeding bronchospasm denervation disease /disorder model dogs electromyography human subject innervation laboratory rabbit laryngeal nerves larynx muscle mechanoreceptors muscle tone newborn animals newborn human (0-6 weeks) paralysis premature infant human pulmonary respiration respiratory airflow disorder respiratory airway pressure respiratory airway volume respiratory hypoxia sudden infant death syndrome tracheotomy vagotomy videotape /videodisc
项目摘要
The overall objective of our research is to study the role of sensory
influences originating from the upper airway on respiratory control in
health and disease. We propose to continue studies on laryngeal afferents
and reflexes in anesthetized spontaneously breathing adult dogs. In
addition, developmental changes in upper airway functions will be studied
in a neonatal dog model. Action potentials from single fibers of the
superior laryngeal nerve and/or electromyogram of various upper airway
muscles will be monitored together with esophageal pressure and laryngeal
temperature in most studies. Their are five main objectives: 1) To
elucidate the mechanism involved in reflex responses elicited by airflow
through the upper airway. the proposed research should establish that
either laryngeal mechanoreceptor inhibitor or cold receptor stimulation or
both are responsible for the ventilatory depression observed during airflow
through the upper airway in neonates, 2) To determine developmental changes
in the effects of intralaryngeal CO2 on breathing pattern. A greater
reflex inhibition of breathing by CO2 is predicted in neonates. 3) To
determine the afferent pathway and characterize the response of afferent
nerve endings mediating the bronchospasm observed during high frequency
pressure oscillations in the upper airway, 4) To investigate the influences
of changes in airway surface liquid composition and osmolality on the
response of laryngeal afferents and characterize further the behavior of
rapidly adapting laryngeal endings, 5) To determine the relative
contribution of various upper airway muscle groups in the maintenance of
upper airway patency. These studies should provide new information on the
processes involved in upper airway maintenance and may clarify our
understanding of the pathophysiology of obstructive sleep apnea, neonatal
apnea and sudden infant death syndrome.
我们研究的总体目标是研究感官的作用
项目成果
期刊论文数量(23)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Afferent activity in the external branch of the superior laryngeal and recurrent laryngeal nerves.
喉上神经和喉返神经外支的传入活动。
- DOI:10.1177/000348949110001115
- 发表时间:1991
- 期刊:
- 影响因子:0
- 作者:Sant'Ambrogio,FB;Tsubone,H;Mathew,OP;Sant'Ambrogio,G
- 通讯作者:Sant'Ambrogio,G
Activation of water-responsive laryngeal afferents: role of epithelial ion transport.
水响应性喉传入的激活:上皮离子运输的作用。
- DOI:10.1016/0034-5687(96)00050-3
- 发表时间:1996
- 期刊:
- 影响因子:0
- 作者:Ghosh,TK;VanScott,MR;Mathew,OP
- 通讯作者:Mathew,OP
Cooling mediates the ventilatory depression associated with airflow through the larynx.
冷却介导与通过喉部的气流相关的通气抑制。
- DOI:10.1016/0034-5687(90)90105-8
- 发表时间:1990
- 期刊:
- 影响因子:0
- 作者:Mathew,OP;Anderson,JW;Orani,GP;Sant'Ambrogio,FB;Sant'Ambrogio,G
- 通讯作者:Sant'Ambrogio,G
Effect of upper airway pressure pulses on breathing pattern.
上呼吸道压力脉冲对呼吸模式的影响。
- DOI:10.1016/0034-5687(86)90140-4
- 发表时间:1986
- 期刊:
- 影响因子:0
- 作者:Woodall,DL;Mathew,OP
- 通讯作者:Mathew,OP
Influence of intralaryngeal CO2 on the response of laryngeal afferents to upper airway negative pressure.
喉内CO2 对喉传入上气道负压反应的影响。
- DOI:10.1152/jappl.1994.76.6.2720
- 发表时间:1994
- 期刊:
- 影响因子:0
- 作者:Ghosh,TK;Mathew,OP
- 通讯作者:Mathew,OP
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
OOMMEN P MATHEW其他文献
OOMMEN P MATHEW的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('OOMMEN P MATHEW', 18)}}的其他基金
CONTROL OF BREATHING: INFLUENCES OF UPPER AIRWAY ORIGIN
呼吸控制:上呼吸道起源的影响
- 批准号:
3344485 - 财政年份:1991
- 资助金额:
$ 10.97万 - 项目类别:
CONTROL OF BREATHING--INFLUENCES OF UPPER AIRWAY ORIGIN
呼吸控制——上呼吸道起源的影响
- 批准号:
3344484 - 财政年份:1984
- 资助金额:
$ 10.97万 - 项目类别:
CONTROL OF BEATHING--INFLUENCES OF UPPER AIRWAY
呼吸的控制——上呼吸道的影响
- 批准号:
3344478 - 财政年份:1984
- 资助金额:
$ 10.97万 - 项目类别:
CONTROL OF BEATHING--INFLUENCES OF UPPER AIRWAY
呼吸的控制——上呼吸道的影响
- 批准号:
3344477 - 财政年份:1984
- 资助金额:
$ 10.97万 - 项目类别:
CONTROL OF BREATHING: INFLUENCES OF UPPER AIRWAY ORIGIN
呼吸控制:上呼吸道起源的影响
- 批准号:
3344483 - 财政年份:1984
- 资助金额:
$ 10.97万 - 项目类别:
CONTROL OF BEATHING--INFLUENCES OF UPPER AIRWAY
呼吸的控制——上呼吸道的影响
- 批准号:
3344481 - 财政年份:1984
- 资助金额:
$ 10.97万 - 项目类别:
CONTROL OF BEATHING--INFLUENCES OF UPPER AIRWAY
呼吸的控制——上呼吸道的影响
- 批准号:
3344482 - 财政年份:1984
- 资助金额:
$ 10.97万 - 项目类别:
CONTROL OF BREATHING--INFLUENCES OF UPPER AIRWAY ORIGINS
呼吸控制——上呼吸道起源的影响
- 批准号:
3344480 - 财政年份:1984
- 资助金额:
$ 10.97万 - 项目类别:
相似海外基金
Development of Triple Heat Flux Method for Robust Wearable Core Body Temperature Measurement
开发用于稳健可穿戴核心体温测量的三重热通量方法
- 批准号:
23K19094 - 财政年份:2023
- 资助金额:
$ 10.97万 - 项目类别:
Grant-in-Aid for Research Activity Start-up
Calorie Restriction, Body Temperature and Alzheimers Disease
热量限制、体温和阿尔茨海默病
- 批准号:
10727319 - 财政年份:2023
- 资助金额:
$ 10.97万 - 项目类别:
Regulated muscle-based thermogenesis for body temperature regulation
调节基于肌肉的生热作用以调节体温
- 批准号:
DP220102018 - 财政年份:2022
- 资助金额:
$ 10.97万 - 项目类别:
Discovery Projects
Energy metabolism and disease sensitivity determined by body temperature: Lessons from hibernation
由体温决定的能量代谢和疾病敏感性:冬眠的教训
- 批准号:
21K19481 - 财政年份:2021
- 资助金额:
$ 10.97万 - 项目类别:
Grant-in-Aid for Challenging Research (Exploratory)
NSF Postdoctoral Fellowship in Biology FY 2021: Using a protoendothermic mammal to understand how body temperature influences nutrient absorption.
2021 财年 NSF 生物学博士后奖学金:利用原吸热哺乳动物了解体温如何影响营养吸收。
- 批准号:
2109649 - 财政年份:2021
- 资助金额:
$ 10.97万 - 项目类别:
Fellowship Award
Practical realization of human body simulation model for predicting body temperature, blood pressure and blood flow rate
预测体温、血压、血流速度的人体仿真模型的实际实现
- 批准号:
20H02307 - 财政年份:2020
- 资助金额:
$ 10.97万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Role of CREG1 on the regulation of thermogenic cells and body temperature
CREG1对产热细胞和体温调节的作用
- 批准号:
20K06450 - 财政年份:2020
- 资助金额:
$ 10.97万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Exploring the molecular mechanisms of body temperature rhythms through a Drosophila model system
通过果蝇模型系统探索体温节律的分子机制
- 批准号:
10440755 - 财政年份:2020
- 资助金额:
$ 10.97万 - 项目类别:
A Low Cost Remote Body Temperature Monitoring and Symptom Diagnosis Solution
低成本远程体温监测和症状诊断解决方案
- 批准号:
69491 - 财政年份:2020
- 资助金额:
$ 10.97万 - 项目类别:
Feasibility Studies
Exploring the molecular mechanisms of body temperature rhythms through a Drosophila model system
通过果蝇模型系统探索体温节律的分子机制
- 批准号:
9979341 - 财政年份:2020
- 资助金额:
$ 10.97万 - 项目类别: