CORE CLINICAL NUTRITION RESEARCH CENTER

核心临床营养研究中心

• 批准号: 3093201
• 负责人: CARLOS L KRUMDIECK
• 金额: $ 73.69万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 1979
• 资助国家: 美国
• 起止时间: 1979-09-30 至 1994-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3093201
• 关键词: biomedical facility; nutrition; nutrition related tag

The primary purpose of the Clinical Nutrition Research Unit at UAB is to generate, promote and strengthen interdisciplinary reseach in clinical and basic nutrition emphasizing prevention of disease. primarily cancer, and the improvement of patient care. The UAB-CNRU is committed to the improvement of nutrition education, from the dissemination of sound nutrition information to the public, to the education of health professionals and investigators in nutrition sciences. To accomplish these goals the CNRU supports an Administrative Core of Key personnel responsible for planning evaluating and managing programmatic and fiscal affairs of a broad spectrum of research and training activities. The provision of shared resources in the form seven Core laboratories/facilities and the support of starter grants for young investigators are the main mechanisms used for promotion of nutrition research. A strong Nutrition Education component and a Nutrition Information Service are central to the attainment of our educational objectives including research on the development, an evaluation of educational methodologies. The CNRU Research Base has expanded more than ten times. Over forty project (twenty-eight are active grants/contracts, and seventeen are in nutrition and cancer benefit from CNRU support via access to Core services, or through funding as CNR pilot projects. The CNRU collaborates with the Comprehensive Cancer Center at UAB an with faculty from clinical and basic sciences Departments campus-wide. Ten collaborative projects with other Universities or Research Institutes, including three CNRU' (UCLA, UC-Davis and Vanderbilt University) and a university abroad, are in progress Recent scientific accomplishments include: Demonstration of improvement in pre-neoplastic lesions of the cervix and the bronchial epithelium by folate and B12 supplementation; complete prevention of experimental mammary cancer in rats by combination estrogen/progesterone treatment; synthesis and evaluation of new potential chemo-preventive retinoids; discovery of a new bone cell-attachment protein possibly in volved in cancer promotion; demonstration of initiation-facilitation of experimental mammary carcinogenesis by ethanol; synthesis of a new type of antisickling compounds development of new methods for the study of body composition, and more. Major additions to our Core facilities include animal facilities for cancer research, and a computerized Image Analysis laboratory soon to become operational.

UAB临床营养研究单位的主要目的是 产生、促进和加强临床跨学科研究 强调预防疾病的基本营养。主要是癌症， 和改善病人护理。UAB-CNRU致力于 改善营养教育，从传播声音， 向公众提供营养信息， 营养科学的专业人员和研究人员。完成 这些目标，CNRU支持关键人员的管理核心 负责规划、评价和管理方案和财政 广泛的研究和培训活动的事务。的 以七个核心方案形式提供共享资源 实验室/设施以及为青年提供启动赠款 调查员是促进营养的主要机制， research.一个强有力的营养教育组成部分和一个营养 信息服务是我们实现教育目标的核心 目标，包括研究发展，评估 教育方法论 CNRU研究基地规模扩大了十倍多。四十多 项目（28个是现行赠款/合同，17个是在 营养和癌症受益于CNRU的支持，通过访问核心 服务，或通过CNR试点项目提供资金。CNRU合作 与UAB的综合癌症中心合作， 和基础科学系。十个合作项目 与其他大学或研究机构，包括三个CNRU' (UCLA，加州大学戴维斯分校和范德比尔特大学）和国外的一所大学，是 最近的科学成就包括： 改善宫颈和支气管的癌前病变 补充叶酸和B12;完全预防 雌孕激素联合治疗大鼠乳腺癌的实验研究 治疗;合成和评价新的潜在化学预防 类维生素A;发现一种新的骨细胞附着蛋白， 参与促进癌症;示范启动-促进 乙醇诱发实验性乳腺癌;一种新的 开发新的研究方法， 身体成分，还有更多。我们核心设施的主要补充 包括用于癌症研究动物设施和计算机化图像 分析实验室即将投入使用。