CORE CLINICAL NUTRITION RESEARCH CENTER

核心临床营养研究中心

• 批准号: 2087693
• 负责人: CARLOS L KRUMDIECK
• 金额: $ 85.23万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 1979
• 资助国家: 美国
• 起止时间: 1979-09-30 至 1995-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2087693
• 关键词: biomedical facility; nutrition; nutrition related tag

The primary purpose of the Clinical Nutrition Research Unit at UAB is to generate, promote and strengthen interdisciplinary reseach in clinical and basic nutrition emphasizing prevention of disease. primarily cancer, and the improvement of patient care. The UAB-CNRU is committed to the improvement of nutrition education, from the dissemination of sound nutrition information to the public, to the education of health professionals and investigators in nutrition sciences. To accomplish these goals the CNRU supports an Administrative Core of Key personnel responsible for planning evaluating and managing programmatic and fiscal affairs of a broad spectrum of research and training activities. The provision of shared resources in the form seven Core laboratories/facilities and the support of starter grants for young investigators are the main mechanisms used for promotion of nutrition research. A strong Nutrition Education component and a Nutrition Information Service are central to the attainment of our educational objectives including research on the development, an evaluation of educational methodologies. The CNRU Research Base has expanded more than ten times. Over forty project (twenty-eight are active grants/contracts, and seventeen are in nutrition and cancer benefit from CNRU support via access to Core services, or through funding as CNR pilot projects. The CNRU collaborates with the Comprehensive Cancer Center at UAB an with faculty from clinical and basic sciences Departments campus-wide. Ten collaborative projects with other Universities or Research Institutes, including three CNRU' (UCLA, UC-Davis and Vanderbilt University) and a university abroad, are in progress Recent scientific accomplishments include: Demonstration of improvement in pre-neoplastic lesions of the cervix and the bronchial epithelium by folate and B12 supplementation; complete prevention of experimental mammary cancer in rats by combination estrogen/progesterone treatment; synthesis and evaluation of new potential chemo-preventive retinoids; discovery of a new bone cell-attachment protein possibly in volved in cancer promotion; demonstration of initiation-facilitation of experimental mammary carcinogenesis by ethanol; synthesis of a new type of antisickling compounds development of new methods for the study of body composition, and more. Major additions to our Core facilities include animal facilities for cancer research, and a computerized Image Analysis laboratory soon to become operational.

UAB临床营养研究部门的主要目的是

项目成果

Dietary folate requirement determined for channel catfish, Ictalurus punctatus.

斑点叉尾鮰的膳食叶酸需求量测定。

• DOI: 10.1093/jn/123.11.1888
• 发表时间: 1993
• 期刊: The Journal of nutrition
• 作者: Duncan,PL;Lovell,RT;ButterworthJr,CE;Freeberg,LE;Tamura,T
• 通讯作者: Tamura,T

Nutrient levels in amniotic fluid from women with normal and neural tube defect pregnancies.

正常和神经管缺陷妊娠妇女羊水中的营养水平。

• DOI: 10.1159/000243747
• 发表时间: 1992
• 期刊: Biology of the neonate
• 作者: Weekes,EW;Tamura,T;Davis,RO;Birch,R;Vaughn,WH;Franklin,JC;Barganier,C;Cosper,P;Finley,SC;Finley,WH
• 通讯作者: Finley,WH

Plasma folate adequacy as determined by homocysteine level.

通过同型半胱氨酸水平确定血浆叶酸充足性。

• DOI: 10.1111/j.1749-6632.1992.tb17123.x
• 发表时间: 1992
• 期刊: Annals of the New York Academy of Sciences
• 影响因子: 5.2
• 作者: Lewis,CA;Pancharuniti,N;Sauberlich,HE
• 通讯作者: Sauberlich,HE

Plasma and urinary levels of biopterin, neopterin, and related pterins and plasma levels of folate in infantile autism.

婴儿自闭症患者血浆和尿液中生物蝶呤、新蝶呤和相关蝶呤的水平以及叶酸的血浆水平。

• DOI: 10.1007/bf01058157
• 发表时间: 1992
• 期刊: Journal of autism and developmental disorders
• 影响因子: 3.9
• 作者: Eto,I;Bandy,MD;ButterworthJr,CE
• 通讯作者: ButterworthJr,CE

Creation of a regional medical-nutrition education network.

建立区域医疗营养教育网络。

• DOI: 10.1093/ajcn/49.1.1
• 发表时间: 1989
• 期刊: The American journal of clinical nutrition
• 作者: Feldman,EB;Borum,PR;DiGirolamo,M;Feldman,DS;Greene,JM;Leonard,SB;Morgan,SL;Moinuddin,JF;Read,MS;Weinsier,RL
• 通讯作者: Weinsier,RL