CORE CLINICAL NUTRITION RESEARCH CENTER

核心临床营养研究中心

• 批准号: 3093208
• 负责人: CARLOS L KRUMDIECK
• 金额: $ 83.83万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 1979
• 资助国家: 美国
• 起止时间: 1979-09-30 至 1994-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3093208
• 关键词: biomedical facility; nutrition; nutrition related tag

The primary purpose of the Clinical Nutrition Research Unit at UAB is to generate, promote and strengthen interdisciplinary reseach in clinical and basic nutrition emphasizing prevention of disease. primarily cancer, and the improvement of patient care. The UAB-CNRU is committed to the improvement of nutrition education, from the dissemination of sound nutrition information to the public, to the education of health professionals and investigators in nutrition sciences. To accomplish these goals the CNRU supports an Administrative Core of Key personnel responsible for planning evaluating and managing programmatic and fiscal affairs of a broad spectrum of research and training activities. The provision of shared resources in the form seven Core laboratories/facilities and the support of starter grants for young investigators are the main mechanisms used for promotion of nutrition research. A strong Nutrition Education component and a Nutrition Information Service are central to the attainment of our educational objectives including research on the development, an evaluation of educational methodologies. The CNRU Research Base has expanded more than ten times. Over forty project (twenty-eight are active grants/contracts, and seventeen are in nutrition and cancer benefit from CNRU support via access to Core services, or through funding as CNR pilot projects. The CNRU collaborates with the Comprehensive Cancer Center at UAB an with faculty from clinical and basic sciences Departments campus-wide. Ten collaborative projects with other Universities or Research Institutes, including three CNRU' (UCLA, UC-Davis and Vanderbilt University) and a university abroad, are in progress Recent scientific accomplishments include: Demonstration of improvement in pre-neoplastic lesions of the cervix and the bronchial epithelium by folate and B12 supplementation; complete prevention of experimental mammary cancer in rats by combination estrogen/progesterone treatment; synthesis and evaluation of new potential chemo-preventive retinoids; discovery of a new bone cell-attachment protein possibly in volved in cancer promotion; demonstration of initiation-facilitation of experimental mammary carcinogenesis by ethanol; synthesis of a new type of antisickling compounds development of new methods for the study of body composition, and more. Major additions to our Core facilities include animal facilities for cancer research, and a computerized Image Analysis laboratory soon to become operational.

阿拉巴马大学临床营养研究室的主要目的是 产生、促进和加强临床跨学科研究 和强调预防疾病的基本营养。主要是癌症， 以及患者护理的改善。 UAB-CNRU 致力于 改善营养教育，从传播声音开始 向公众提供营养信息，进行健康教育 营养科学领域的专业人士和研究人员。为了完成 CNRU 支持关键人员的行政核心来实现这些目标 负责规划、评估和管理计划和财务 广泛的研究和培训活动事务。这 以七个核心形式提供共享资源 实验室/设施以及对年轻人的启动补助金的支持 调查员是促进营养的主要机制 研究。强大的营养教育成分和营养 信息服务对于实现我们的教育至关重要 目标包括发展研究、评估 教育方法论。 CNRU研究基地已扩大十余倍。四十多岁 项目（二十八个是有效的赠款/合同，十七个是在 通过访问核心，CNRU 支持使营养和癌症受益 服务，或通过 CNR 试点项目提供资金。 CNRU 合作 与 UAB 综合癌症中心和临床教职人员合作 和全校基础科学系。十个合作项目 与其他大学或研究机构合作，包括三所 CNRU' （加州大学洛杉矶分校、加州大学戴维斯分校和范德比尔特大学）和国外的一所大学 正在进行中 最近的科学成就包括： 宫颈和支气管肿瘤前病变的改善 通过补充叶酸和 B12 来促进上皮细胞生长；彻底预防 雌激素/孕激素联合治疗大鼠实验性乳腺癌 治疗;新型潜在化学预防药物的合成与评价 类维生素A；发现一种新的骨细胞附着蛋白可能 参与癌症宣传；示范启动-促进 乙醇引起的实验性乳腺癌；新型合成 抗镰化化合物的研究新方法的开发 身体成分等等。我们的核心设施的主要新增内容 包括用于癌症研究的动物设施和计算机图像 分析实验室即将投入运行。