Developmental genes in the life cycle of a parasitic flatworm

寄生扁虫生命周期中的发育基因

• 批准号: BB/G003815/1
• 负责人: Peter Olson
• 金额: $ 34.48万
• 依托单位: Natural History Museum
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2009
• 资助国家: 英国
• 起止时间: 2009 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FG003815%2F1
• 关键词: Developmental; genes; life; cycle; parasitic

Tapeworms are a group of more than 10,000 known species adversely affecting the health of both ourselves and our domesticated animals. Their complex life histories centre on the maintenance of a germinative 'neck' region that produces a continuous chain of segments throughout their lives, each replete with male and female reproductive organs capable of producing an enormous number of new infections. Genetic mechanisms underpinning their development are unknown, but have implications for both understanding novel means of therapeutic intervention as well as understanding basic developmental processes in the animal kingdom. This research will examine the roles of Hox and other developmental genes that act to coordinate embryonic axial patterning and other aspects of development throughout the animal kingdom (e.g. establishing which end will develop into the 'head' and which into the 'tail'). By understanding the actions of these genes, this research will resolve fundamental questions regarding how tapeworms became segmented to enable their parasitic lifestyle and how Hox genes are used in the complex development of a parasitic animal. In turn, this will provide a platform for future research on development in other parasitic flatworm groups.

绦虫是一组超过10，000种已知的物种，对我们自己和我们驯养的动物的健康产生不利影响。它们复杂的生活史集中在维持一个发芽的“颈部”区域，在它们的一生中产生一个连续的片段链，每个片段都充满了能够产生大量新感染的男性和女性生殖器官。支持其发展的遗传机制尚不清楚，但对于理解新的治疗干预手段以及理解动物王国的基本发育过程都有影响。这项研究将研究Hox和其他发育基因的作用，这些基因在整个动物王国中协调胚胎轴向模式和其他发育方面（例如，确定哪一端将发育成“头”，哪一端将发育成“尾”）。通过了解这些基因的作用，这项研究将解决有关绦虫如何被分割以实现其寄生生活方式以及Hox基因如何用于寄生动物复杂发育的基本问题。反过来，这将为今后研究其他寄生扁虫群体的发展提供一个平台。

项目成果

Description of Hymenolepis microstoma (Nottingham strain): a classical tapeworm model for research in the genomic era.

• DOI: 10.1186/1756-3305-3-123
• 发表时间: 2010-12-31
• 期刊: Parasites & vectors
• 影响因子: 3.2
• 作者: Cunningham LJ;Olson PD
• 通讯作者: Olson PD

Genome-wide transcriptome profiling and spatial expression analyses identify signals and switches of development in tapeworms.

• DOI: 10.1186/s13227-018-0110-5
• 发表时间: 2018
• 期刊: EvoDevo
• 影响因子: 4.1
• 作者: Olson PD;Zarowiecki M;James K;Baillie A;Bartl G;Burchell P;Chellappoo A;Jarero F;Tan LY;Holroyd N;Berriman M
• 通讯作者: Berriman M

Spatial and temporal consistency of putative reference genes for real-time PCR in a model tapeworm.

绦虫模型中实时 PCR 推定参考基因的空间和时间一致性。

• DOI: 10.1016/j.molbiopara.2011.08.004
• 发表时间: 2011
• 期刊: Molecular and biochemical parasitology
• 影响因子: 1.5
• 作者: Pouchkina-Stantcheva NN

RNA-mediated gene suppression and in vitro culture in Hymenolepis microstoma.

• DOI: 10.1016/j.ijpara.2013.03.004
• 发表时间: 2013-07
• 期刊: International journal for parasitology
• 影响因子: 4
• 作者: Natalia N. Pouchkina-Stantcheva;Lucas J. Cunningham;G. Hrčková;P. Olson