DNA exhibits new self-assembled structures due to clustered DNA methylation

由于DNA簇甲基化，DNA呈现出新的自组装结构

• 批准号: DP180102868
• 负责人: Prof Matt Trau
• 金额: $ 23.98万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-02-07 至 2021-02-28
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP180102868
• 关键词: DNA; exhibits; new; self; assembled

This project aims to develop a technology to investigate detailed epigenetic patterns in DNA by directly interrogating the physical properties of DNA polymers in their native state. Epigenetics controls whether genes and genetic programs are turned on or off in living systems. The project will build on a recent discovery that key physical properties of native DNA polymers are strongly influenced by epigenetic patterns created by living organisms. By fully understanding this phenomenon, this project aims to provide new tools for the study of epigenetics with broad potential applications in the life sciences, biotechnology and nanotechnology.

该项目旨在开发一种技术，通过直接询问DNA聚合物在其自然状态下的物理性质来研究DNA中详细的表观遗传模式。表观遗传学控制着生命系统中基因和遗传程序的开启或关闭。该项目将建立在最近的一项发现基础上，即天然DNA聚合物的关键物理性质受到生物创造的表观遗传模式的强烈影响。通过充分了解这一现象，该项目旨在为表观遗传学的研究提供新的工具，在生命科学、生物技术和纳米技术中具有广泛的潜在应用。