An integrated nano-bioengineered chip for enhanced molecular evolution

本项目旨在开发一种新的分子进化平台技术，利用涂有靶标的电激活纳米流控芯片，从不同的分子库中快速选择高价值的靶标结合分子。该项目的重要成果是控制目标结合分子的选择，这是目前方法无法实现的，并提高了对纳米生物工程表面上纳米力驱动的分子碰撞的理解。这带来了巨大的好处，在纳米材料和纳米制造设备的先进制造方面创造了新的知识，创造了商业利益，并将澳大利亚定位在分子发现技术的前沿，这是一个非常有价值的全球市场。

This project aims to develop a novel molecular evolution platform technology for the rapid selection of high value target binding molecules from diverse molecular libraries using an electrically activated nanofluidic chip coated with target. Significant outcomes from the project is the controlled selection of target binding molecules that is not possible with current methods and improved understanding of nanoforce driven molecular collisions on nano-bioengineered surfaces. This provides significant benefits, creating new knowledge in nanomaterials and advanced manufacturing of nanofabricated devices, creating commercial interest and positioning Australia at the forefront of molecular discovery technology, a highly valuable global market.