An integrated nano-bioengineered chip for enhanced molecular evolution

用于增强分子进化的集成纳米生物工程芯片

• 批准号: DP220100960
• 负责人: Prof Matt Trau
• 金额: $ 33.6万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2022
• 资助国家: 澳大利亚
• 起止时间: 2022-01-21 至 2025-01-20
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP220100960
• 关键词: integrated; nano; bioengineered; chip; enhanced

This project aims to develop a novel molecular evolution platform technology for the rapid selection of high value target binding molecules from diverse molecular libraries using an electrically activated nanofluidic chip coated with target. Significant outcomes from the project is the controlled selection of target binding molecules that is not possible with current methods and improved understanding of nanoforce driven molecular collisions on nano-bioengineered surfaces. This provides significant benefits, creating new knowledge in nanomaterials and advanced manufacturing of nanofabricated devices, creating commercial interest and positioning Australia at the forefront of molecular discovery technology, a highly valuable global market.

本项目旨在开发一种新型的分子进化平台技术，用于使用涂覆有靶标的电激活纳米流控芯片从不同的分子库中快速选择高价值的靶标结合分子。该项目的重要成果是目标结合分子的受控选择，这是目前方法无法实现的，并提高了对纳米生物工程表面上纳米力驱动分子碰撞的理解。这带来了巨大的利益，创造了纳米材料和纳米制造设备先进制造的新知识，创造了商业利益，并将澳大利亚置于分子发现技术的最前沿，这是一个非常有价值的全球市场。