DEVELOPMENT OF A NOVEL BIOMATERIAL FOR BONE TISSUE ENGINEERING

开发用于骨组织工程的新型生物材料

• 批准号: DP0343547
• 负责人: Prof Matt Trau
• 金额: $ 6.14万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2003
• 资助国家: 澳大利亚
• 起止时间: 2003-01-01 至 2005-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0343547
• 关键词: DEVELOPMENT; NOVEL; BIOMATERIAL; BONE; TISSUE

Tissue engineering of bone is emerging as a viable therapy for treating large defects in load-bearing bone. We wish to develop methods for combining novel heparan sulphate molecules (known to deliver growth factors to cell surfaces and thereby cause changes in bone cell phenotype) with load-bearing, macro-porous, biodegradable mineral/polymer biomaterials. Through the study of release profiles, protein adsorption and cell responses to these derivatised biomaterials, a novel approach to bone replacement materials can be developed.

骨组织工程是治疗承重骨大面积缺损的一种有效方法。我们希望开发将新型硫酸乙酰肝素分子（已知将生长因子递送至细胞表面，从而引起骨细胞表型的变化）与承重、大孔、可生物降解的矿物/聚合物生物材料相结合的方法。通过研究这些衍生化生物材料的释放曲线、蛋白质吸附和细胞反应，可以开发一种新的骨替代材料。