Tuneable “Nano-Shearing”: An Innovative Mechanism for the Accurate and Specific Capture of Cells and Molecules

可调谐“纳米剪切”：一种精确、特异性捕获细胞和分子的创新机制

• 批准号: DP140104006
• 负责人: Prof Matt Trau
• 金额: $ 23.27万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP140104006
• 关键词: Tuneable; Nano; Shearing; Innovative; Mechanism

Recent investigations have discovered a tuneable electro-hydrodynamic force which drives lateral fluid motion within a few nanometers of an electrode surface. Because the magnitude of this fluid shear force can be tuned externally (for example, via the application of an AC electric field), it provides a new capability to physically displace weakly (non-specifically) bound cellular and molecular analytes. By performing research to further understand and develop this tuneable effect, this project aims to build and test a new platform technology to enable highly efficient capture and specific detection of low concentration pathogenic molecules and circulating tumour cells (CTCs).

最近的研究已经发现了一种可调的电流体动力，其驱动电极表面几纳米内的横向流体运动。 由于这种流体剪切力的大小可以在外部调节（例如，通过施加AC电场），因此它提供了物理置换弱（非特异性）结合的细胞和分子分析物的新能力。通过研究进一步了解和开发这种可调效应，该项目旨在建立和测试一种新的平台技术，以实现对低浓度致病分子和循环肿瘤细胞（CTC）的高效捕获和特异性检测。