Trapping and Watching Biomolecular Complexes near Nanopores

捕获和观察纳米孔附近的生物分子复合物

• 批准号: DP160102836
• 负责人: Prof Matt Trau
• 金额: $ 22.07万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP160102836
• 关键词: Trapping; Watching; Biomolecular; Complexes; near

This project aims to develop a technology to trap and interrogate nanosized molecular complexes in their natural state. Nanosized complexes in water provide the core machinery of biological systems and require detailed understanding to help unravel fundamental biological mechanisms. A prototype of a methodology has been developed to trap and interrogate nanoscaled objects as small as 190 nanometres within a nanopore device. By performing research to fully understand, miniaturise and develop this method further, this project aims to enable the quantitative observation of nanoscaled biological machinery involved in cell-to-cell communication and DNA unfolding. Such a technology platform may have applications in areas such as biology, biotechnology and advanced materials.

该项目旨在开发一种技术来捕获和询问其自然状态的纳米化分子复合物。水中的纳米化络合物提供了生物系统的核心机制，并需要详细的理解以帮助解开基本的生物学机制。已经开发了一种方法论的原型，以捕获和询问纳米孔设备中190纳米的纳米级对象。通过进行研究以充分理解，小型化和开发此方法，该项目旨在使纳米级生物机械的定量观察与细胞间通信和DNA展开有关。这样的技术平台可能在生物学，生物技术和高级材料等领域中有应用。