Trapping and Watching Biomolecular Complexes near Nanopores

捕获和观察纳米孔附近的生物分子复合物

• 批准号: DP160102836
• 负责人: Prof Matt Trau
• 金额: $ 22.07万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP160102836
• 关键词: Trapping; Watching; Biomolecular; Complexes; near

This project aims to develop a technology to trap and interrogate nanosized molecular complexes in their natural state. Nanosized complexes in water provide the core machinery of biological systems and require detailed understanding to help unravel fundamental biological mechanisms. A prototype of a methodology has been developed to trap and interrogate nanoscaled objects as small as 190 nanometres within a nanopore device. By performing research to fully understand, miniaturise and develop this method further, this project aims to enable the quantitative observation of nanoscaled biological machinery involved in cell-to-cell communication and DNA unfolding. Such a technology platform may have applications in areas such as biology, biotechnology and advanced materials.

该项目旨在开发一种捕获和询问自然状态下的纳米分子复合物的技术。水中的纳米复合物提供了生物系统的核心机制，需要详细的了解才能帮助揭示基本的生物机制。已经开发出一种方法原型，用于捕获和询问纳米孔装置内小至 190 纳米的纳米级物体。通过开展研究以充分理解、微型化和进一步开发这种方法，该项目旨在定量观察参与细胞间通讯和 DNA 展开的纳米级生物机器。这样的技术平台可能在生物学、生物技术和先进材料等领域有应用。