Single molecule sensing on nanopillars: Reading complex molecular circuits

纳米柱上的单分子传感：读取复杂的分子电路

• 批准号: DP210103151
• 负责人: Prof Matt Trau
• 金额: $ 23.9万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP210103151
• 关键词: Single; molecule; sensing; nanopillars; Reading

This project aims to develop an entirely new nanotechnology to visualise dynamic molecular circuits in real time, and within any biological sample as small as a single cell. This project expects to generate new knowledge in the field of cell biology and sensor technology, using innovative nanofabrication and nanoscopic fluid flows to advance understanding of the emerging field of single protein molecule interactions in cellular pathways. Expected outcomes include a universal technology platform to detect single molecules in single cells, with potential to deliver valuable intellectual property of commercial interest and economic benefit through technological advancements.

该项目旨在开发一种全新的纳米技术，以实时可视化动态分子回路，并在任何像单个细胞一样小的生物样品中。该项目希望使用创新的纳米化和纳米镜流动，从而在细胞生物学和传感器技术领域产生新知识，以提高对细胞途径中单蛋白分子相互作用的新兴领域的了解。预期的结果包括一个通用技术平台来检测单个细胞中的单个分子，并有可能通过技术进步提供有价值的商业利益和经济利益的知识产权。