ALCOHOLIC LIVER PATHOLOGY: HEPATIC CEREBRAL INTERACTION

拟议的研究调查的机制， 神经功能缺损与社会适应和角色表现 酗酒者。 具体而言，肝脏的类型和严重程度 将对酗酒者的疾病进行组织学评估， 生物化学上关于大小和具体表现 通过神经心理学测试测量的神经功能缺损，临床 神经系统检查和在一个子集的情况下，通过磁 共振成像 这些研究将阐明 肝性脑病和特殊的内在病理性 肝脏疾病的并发症决定了神经系统后遗症 酒精中毒 第二项研究将评估原位肝移植的效果。 移植对神经功能缺损恢复的影响， 改善酗酒者的心理社会适应。 这些 结果将提供重要的新信息， 酒精性肝病的协调医疗管理可以增加 酗酒者的康复

The proposed research investigate the mechanisms underlying neurologic impairment and social adjustment and role performance in alcoholics. Specifically, the type and severity of liver disease in alcoholics will be evaluated histologically and biochemically with respect to magnitude and specific manifestation of neurologic deficit measured by neuropsychological test, clinical neurologic examination and in a subset of cases, by magnetic resonance imaging. These studies will clarify the extent to which an hepatic encephalopathy and the particular intrinsic pathologic concomitants of hepatic disease determine the neurologic sequelae of alcoholism. A second study will evaluate the effects of orthotopic hepatic transplantation on recovery of neurologic impairment and improvement in psychosocial adjustment of alcoholics. These results will provide important new information regarding whether concerted medical management of alcoholic liver disease can augment the rehabilitation of alcoholics.